Evidence map›Paper›PMID 34828323›Full record

ArticleGenes2021

The Expression of RAAS Key Receptors,

Marite Punapart, Kadri Seppa, Toomas Jagomäe, Mailis Liiv, Riin Reimets, Silvia Kirillov, Allen Kaasik, Lieve Moons, Lies De Groef, Anton Terasmaa and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Marite PunapartLaboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.
Kadri SeppaLaboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.ORCID 0000-0002-6406-7920
Toomas JagomäeLaboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.
Mailis LiivDepartment of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.ORCID 0000-0001-6203-4810
Riin ReimetsLaboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.
Silvia KirillovLaboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.
Allen KaasikDepartment of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.
Lieve MoonsResearch Group Neural Circuit Development and Regeneration, Department of Biology, University of Leuven, Naamsestraat 61, Box 2464, 3000 Leuven, Belgium.ORCID 0000-0003-0186-1411
Lies De GroefResearch Group Neural Circuit Development and Regeneration, Department of Biology, University of Leuven, Naamsestraat 61, Box 2464, 3000 Leuven, Belgium.ORCID 0000-0002-3329-3474
Anton TerasmaaLaboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.
Eero VasarDepartment of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.ORCID 0000-0001-5226-345X
Mario PlaasLaboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.
University of Tartu · EEKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wolfram syndrome (WS) 1 is a rare monogenic neurodegenerative disorder caused by mutations in the gene encoding WFS1. Knowledge of the pathophysiology of WS is incomplete and to date, there is no treatment available. Here, we describe early deviations in the renin-angiotensin-aldosterone system (RAAS) and bradykinin pathway (kallikrein kinin system, KKS) observed in a rat model of WS (

Indexed as

Down-RegulationAldosteroneAnimalsCalmodulin-Binding ProteinsCells, CulturedDisease Models, AnimalGene Knockout TechniquesLiraglutideMaleMembrane ProteinsRatsReceptor, Angiotensin, Type 2Receptor, Bradykinin B1Renin-Angiotensin SystemValproic AcidWolfram SyndromeAgtr2 protein, ratAldosteroneCalmodulin-Binding ProteinsLiraglutideMembrane ProteinsReceptor, Angiotensin, Type 2Receptor, Bradykinin B1Valproic AcidWFS1 protein, ratAgtr2aldosteroneBdkrb1bradykininliraglutideRAASvalproic acidWfs1Wfs1 knock-outWolfram syndrome

Identifiers

PMID34828323
PMCPMC8621801
OpenAlexW3211105320

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.