Evidence map›Paper›PMID 34828710›Full record

ReviewChildren (Basel, Switzerland)2021

Nasal Polyps in Children: The Early Origins of a Challenging Adulthood Condition.

Maria E Di Cicco, Francesca Bizzoco, Elena Morelli, Veronica Seccia, Vincenzo Ragazzo, Diego G Peroni, Pasquale Comberiati

Open access · goldAbstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Laser nasal surgery (Review).Experimental and therapeutic medicine · 2023
    Review
  6. Article
  7. Current Insights on the Impact of Proteomics in Respiratory Allergies.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Maria E Di CiccoDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma n. 55, 56126 Pisa, Italy.ORCID 0000-0002-7027-6817
Francesca BizzocoDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma n. 55, 56126 Pisa, Italy.
Elena MorelliDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma n. 55, 56126 Pisa, Italy.
Veronica SecciaOtolaryngology, Audiology, and Phoniatric Operative Unit, Department of Surgical, Medical, Molecular Pathology, and Critical Care Medicine, Pisa University Hospital, Via Trivella, 56124 Pisa, Italy.ORCID 0000-0002-6297-8034
Vincenzo RagazzoPaediatrics and Neonatology Division, Women's and Children's Health Department, Versilia Hospital, Via Aurelia n. 335, 55049 Lido di Camaiore, Italy.
Diego G PeroniDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma n. 55, 56126 Pisa, Italy.ORCID 0000-0002-0234-1373
Pasquale ComberiatiDepartment of Clinical and Experimental Medicine, University of Pisa, Via Roma n. 55, 56126 Pisa, Italy.ORCID 0000-0001-5209-9733
University of Pisa · ITAzienda Ospedaliera Universitaria Pisana · ITOspedale Versilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nasal polyps (NPs) are benign inflammatory masses causing chronic nasal obstruction, usually associated with underlying chronic rhinosinusitis (CRS), which are rarely reported in childhood. The interest in NPs has recently increased due to new therapeutic options, namely biological agents, such as dupilumab, and an update of the European position paper on this topic was released in 2020, providing a detailed classification for these lesions and also discussing diagnostic and therapeutic approaches also in children. In childhood, NPs usually represent red flags for systemic diseases, such as cystic fibrosis and immunodeficiencies. This review outlines the recent data on NPs in childhood, focusing on predisposing factors for CRS as well as on the potential endotypes in this particular age group, for which further studies are required in order to better clarify their pathogenesis and to identify molecular biomarkers that could help achieve more personalized treatments.

Indexed as

adolescentsasthmabiologicalschildrenchronic rhinosinusitisdupilumabeosinophilsnasal polyposistype 2 inflammation

Identifiers

PMID34828710
PMCPMC8620101
OpenAlexW3208946318

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.