Evidence map›Paper›PMID 34829493›Full record

ReviewDiagnostics (Basel, Switzerland)2021

Primary Psychosis: Risk and Protective Factors and Early Detection of the Onset.

Claudio Brasso, Benedetta Giordano, Cristina Badino, Silvio Bellino, Paola Bozzatello, Cristiana Montemagni, Paola Rocca

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Understanding Psychotic Depression.Advances in experimental medicine and biology · 2026
    Review
  2. Synergistic pathways to psychosis: understanding developmental risk and resilience factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  3. Article
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  9. Review
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  12. Making meaning of multimorbidity and severe mental illness: A viewpoint.The Australian and New Zealand journal of psychiatry · 2024
    Article
  13. Stress, Environment and Early Psychosis.Current neuropharmacology · 2024
    Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Claudio BrassoDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco n. 15, 10126 Turin, Italy.
Benedetta GiordanoDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco n. 15, 10126 Turin, Italy.
Cristina BadinoDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco n. 15, 10126 Turin, Italy.
Silvio BellinoDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco n. 15, 10126 Turin, Italy.ORCID 0000-0002-6555-8000
Paola BozzatelloDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco n. 15, 10126 Turin, Italy.
Cristiana MontemagniDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco n. 15, 10126 Turin, Italy.
Paola RoccaDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco n. 15, 10126 Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary psychosis, which includes schizophrenia and other psychoses not caused by other psychic or physical conditions, has a strong impact worldwide in terms of disability, suffering and costs. Consequently, improvement of strategies to reduce the incidence and to improve the prognosis of this disorder is a current need. The purpose of this work is to review the current scientific literature on the main risk and protective factors of primary psychosis and to examine the main models of prevention, especially those related to the early detection of the onset. The conditions more strongly associated with primary psychosis are socio-demographic and economic factors such as male gender, birth in winter, ethnic minority, immigrant status, and difficult socio-economic conditions while the best-established preventive factors are elevated socio-economic status and an economic well-being. Risk and protective factors may be the targets for primordial, primary, and secondary preventive strategies. Acting on modifiable factors may reduce the incidence of the disorder or postpone its onset, while an early detection of the new cases enables a prompt treatment and a consequential better prognosis. According to this evidence, the study of the determinants of primary psychosis has a pivotal role in designing and promoting preventive policies aimed at reducing the burden of disability and suffering of the disorder.

Indexed as

duration of illness (DOI)duration of untreated psychosis (DUP)early detectionincidenceonsetpreventionprodromal stageprognosisrisk stratificationschizophrenia

Identifiers

PMID34829493
PMCPMC8622963

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.