Evidence map›Paper›PMID 34829990›Full record

ArticleInternational journal of molecular sciences2021

Molecular and Metabolic Mechanism of Low-Intensity Pulsed Ultrasound Improving Muscle Atrophy in Hindlimb Unloading Rats.

Lijun Sun, Shasha An, Zhihao Zhang, Yaling Zhou, Yanan Yu, Zhanke Ma, Xiushan Fan, Liang Tang, Jianzhong Guo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Energy production pathways of female soccer players during championships: a metabolomics approach.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article
  3. Article
  4. [Advances of low-intensity pulsed ultrasound for treatment of musculoskeletal disorders in the past decade].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lijun SunInstitute of Sports Biology, Shaanxi Normal University, Xi'an 710119, China.
Shasha AnInstitute of Sports Biology, Shaanxi Normal University, Xi'an 710119, China.
Zhihao ZhangInstitute of Sports Biology, Shaanxi Normal University, Xi'an 710119, China.
Yaling ZhouInstitute of Sports Biology, Shaanxi Normal University, Xi'an 710119, China.
Yanan YuInstitute of Sports Biology, Shaanxi Normal University, Xi'an 710119, China.
Zhanke MaInstitute of Sports Biology, Shaanxi Normal University, Xi'an 710119, China.
Xiushan FanInstitute of Sports Biology, Shaanxi Normal University, Xi'an 710119, China.
Liang TangInstitute of Sports Biology, Shaanxi Normal University, Xi'an 710119, China.
Jianzhong GuoShaanxi Key Laboratory of Ultrasonics, Shaanxi Normal University, Xi'an 710119, China.
Shaanxi Normal University · CN

Funding

Fundamental Research Funds for the Central Universities GK202103123National Natural Science Foundation of China 11974233, 11727813, 11774213Natural Science Foundation of Shaanxi Province 2018JM1022
6 · The paper itself

Abstract

Low-intensity pulsed ultrasound (LIPUS) has been proved to promote the proliferation of myoblast C2C12. However, whether LIPUS can effectively prevent muscle atrophy has not been clarified, and if so, what is the possible mechanism. The aim of this study is to evaluate the effects of LIPUS on muscle atrophy in hindlimb unloading rats, and explore the mechanisms. The rats were randomly divided into four groups: normal control group (NC), hindlimb unloading group (UL), hindlimb unloading plus 30 mW/cm

Indexed as

Ultrasonic WavesActivin Receptors, Type IIAnimalsCell DifferentiationCell ProliferationDisease Models, AnimalGene Expression RegulationHindlimbHindlimb SuspensionHumansMuscle Fibers, SkeletalMuscle, SkeletalMuscular AtrophyMyoblastsMyostatinRatsActivin Receptors, Type IIMstn protein, ratMyostatinlow intensity pulsed ultrasoundmetabonomicsmuscle atrophymyostatin

Identifiers

PMID34829990
PMCPMC8625684
OpenAlexW3214424392

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.