Evidence map›Paper›PMID 34830044›Full record

ArticleInternational journal of molecular sciences2021

Gender-Related Differences in BMP Expression and Adult Hippocampal Neurogenesis within Joint-Hippocampal Axis in a Rat Model of Rheumatoid Arthritis.

Hrvoje Omrčen, Sanja Zoričić Cvek, Lara Batičić, Sandra Šućurović, Tanja Grubić Kezele

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Neurobehavioral Consequences of Obesity: The Role of Inflammation.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Hrvoje OmrčenDepartment of Anatomy, Faculty of Medicine, University of Rijeka, Braće Branchetta 20, 51000 Rijeka, Croatia.ORCID 0000-0003-1965-7355
Sanja Zoričić CvekDepartment of Anatomy, Faculty of Medicine, University of Rijeka, Braće Branchetta 20, 51000 Rijeka, Croatia.
Lara BatičićDepartment of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, University of Rijeka, Braće Branchetta 20, 51000 Rijeka, Croatia.ORCID 0000-0002-2837-4157
Sandra ŠućurovićDepartment of Hematology, Medical Centre Ljubljana, Zaloška 7, 1000 Ljubljana, Slovenia.
Tanja Grubić KezeleDepartment of Physiology, Immunology and Pathophysiology, Faculty of Medicine, University of Rijeka, Braće Branchetta 20, 51000 Rijeka, Croatia.ORCID 0000-0001-6769-5263
University of Rijeka · HRLjubljana University Medical Centre · SIUniversity Hospital Centre Zagreb · HR

Funding

University of Rijeka uniri-biomed-18-197University of Rijeka uniri-biomed-18-41
6 · The paper itself

Abstract

BMPs regulate synovial quiescence and adult neurogenesis in the hippocampus in non-stress conditions. However, changes in BMP expression that are induced by inflammation during rheumatoid arthritis (RA) have not yet been reported. Here, we show that signalling with synovial BMPs (BMP-4 and -7) mediates the effect of systemic inflammation on adult neurogenesis in the hippocampus during pristane-induced arthritis (PIA) in

Indexed as

NeurogenesisAgingAnimalsArthritis, ExperimentalArthritis, RheumatoidBone Morphogenetic Protein 4Bone Morphogenetic Protein 7Bone Morphogenetic ProteinsCarrier ProteinsCytokinesDoublecortin ProteinFemaleHippocampusInflammationInterleukin-17JointsBmp4 protein, ratBmp7 protein, ratBone Morphogenetic Protein 4Bone Morphogenetic Protein 7Bone Morphogenetic ProteinsCarrier ProteinsCytokinesDcx protein, ratDoublecortin ProteinGrem1 protein, ratIl17a protein, ratInterleukin-17Ki-67 AntigenNoggin ProteinpristaneSOXB1 Transcription FactorsTerpenesTumor Necrosis Factor-alphaadult neurogenesisbone morphogenetic proteinsGremlinhippocampusinterleukin-17Nogginrheumatoid arthritistumor necrosis factor-alpha

Identifiers

PMID34830044
PMCPMC8620092
OpenAlexW3212478768

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.