Evidence map›Paper›PMID 34830156›Full record

ArticleInternational journal of molecular sciences2021

Encapsulin Based Self-Assembling Iron-Containing Protein Nanoparticles for Stem Cells MRI Visualization.

Anna N Gabashvili, Stepan S Vodopyanov, Nelly S Chmelyuk, Viktoria A Sarkisova, Konstantin A Fedotov, Maria V Efremova, Maxim A Abakumov

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Anna N GabashviliDepartment of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, Ostrovityanova St., 1, 117997 Moscow, Russia.
Stepan S VodopyanovLaboratory "Biomedical Nanomaterials", National University of Science and Technology "MISiS", Leninskiy Prospect, 4, 119049 Moscow, Russia.ORCID 0000-0003-1429-9835
Nelly S ChmelyukDepartment of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, Ostrovityanova St., 1, 117997 Moscow, Russia.
Viktoria A SarkisovaBiological Faculty, Lomonosov Moscow State University, Leninskiy Gory, 1, 119234 Moscow, Russia.
Konstantin A FedotovDepartment of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, Ostrovityanova St., 1, 117997 Moscow, Russia.
Maria V EfremovaDepartment of Chemistry and TUM School of Medicine, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.ORCID 0000-0002-5196-5596
Maxim A AbakumovDepartment of Medical Nanobiotechnology, Pirogov Russian National Research Medical University, Ostrovityanova St., 1, 117997 Moscow, Russia.
National University of Science and Technology · RUEngelhardt Institute of Molecular Biology · RUHelmholtz Zentrum München · DE

Funding

Russian Science Foundation 19-45-06302
6 · The paper itself

Abstract

Over the past decade, cell therapy has found many applications in the treatment of different diseases. Some of the cells already used in clinical practice include stem cells and CAR-T cells. Compared with traditional drugs, living cells are much more complicated systems that must be strictly controlled to avoid undesirable migration, differentiation, or proliferation. One of the approaches used to prevent such side effects involves monitoring cell distribution in the human body by any noninvasive technique, such as magnetic resonance imaging (MRI). Long-term tracking of stem cells with artificial magnetic labels, such as magnetic nanoparticles, is quite problematic because such labels can affect the metabolic process and cell viability. Additionally, the concentration of exogenous labels will decrease during cell division, leading to a corresponding decrease in signal intensity. In the current work, we present a new type of genetically encoded label based on encapsulin from

Indexed as

AnimalsBacterial ProteinsCation Transport ProteinsCell DifferentiationCells, CulturedCell SurvivalCeruloplasminHumansIronMagnetic Resonance ImagingMagnetite NanoparticlesMesenchymal Stem CellsMiceMicroscopy, ConfocalMicroscopy, Electron, TransmissionMyxococcus xanthusBacterial ProteinsCation Transport ProteinsCeruloplasminIronMagnetite NanoparticlesSLC39A14 protein, mousecell trackingencapsulinsmagnetic resonance imaging

Identifiers

PMID34830156
PMCPMC8618560
OpenAlexW3212179177

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.