Evidence mapPaperPMID 34830308Full record

ArticleInternational journal of molecular sciences2021

Contribution of the Transcription Factors Sp1/Sp3 and AP-1 to

Christelle Gross, Gaëtan Le-Bel, Pascale Desjardins, Manel Benhassine, Lucie Germain, Sylvain L Guérin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
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  7. Review
  8. Article
  9. ETS1-HMGA2 Axis Promotes Human Limbal Epithelial Stem Cell Proliferation.Investigative ophthalmology & visual science · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Christelle GrossCentre Universitaire d'Ophtalmologie-Recherche (CUO-Recherche), Centre de Recherche du CHU de Québec, Axe Médecine Régénératrice, Hôpital du Saint-Sacrement, Québec, QC G1S 4L8, Canada.
Gaëtan Le-BelCentre Universitaire d'Ophtalmologie-Recherche (CUO-Recherche), Centre de Recherche du CHU de Québec, Axe Médecine Régénératrice, Hôpital du Saint-Sacrement, Québec, QC G1S 4L8, Canada.
Pascale DesjardinsCentre Universitaire d'Ophtalmologie-Recherche (CUO-Recherche), Centre de Recherche du CHU de Québec, Axe Médecine Régénératrice, Hôpital du Saint-Sacrement, Québec, QC G1S 4L8, Canada.
Manel BenhassineCentre Universitaire d'Ophtalmologie-Recherche (CUO-Recherche), Centre de Recherche du CHU de Québec, Axe Médecine Régénératrice, Hôpital du Saint-Sacrement, Québec, QC G1S 4L8, Canada.
Lucie GermainCentre Universitaire d'Ophtalmologie-Recherche (CUO-Recherche), Centre de Recherche du CHU de Québec, Axe Médecine Régénératrice, Hôpital du Saint-Sacrement, Québec, QC G1S 4L8, Canada.ORCID 0000-0001-8883-6491
Sylvain L GuérinCentre Universitaire d'Ophtalmologie-Recherche (CUO-Recherche), Centre de Recherche du CHU de Québec, Axe Médecine Régénératrice, Hôpital du Saint-Sacrement, Québec, QC G1S 4L8, Canada.
Hôpital du Saint-Sacrement · CA

Funding

CIHR FDN-143213
6 · The paper itself

Abstract

In order to reduce the need for donor corneas, understanding of corneal wound healing and development of an entirely tissue-engineered human cornea (hTECs) is of prime importance. In this study, we exploited the hTEC to determine how deep wound healing affects the transcriptional pattern of corneal epithelial cells through microarray analyses. We demonstrated that the gene encoding

Indexed as

Gene ExpressionAdultAgedCells, CulturedChildClusterinEpithelial CellsEpithelium, CornealFibroblastsHumansMiddle AgedPromoter Regions, GeneticSignal TransductionSp1 Transcription FactorSp3 Transcription FactorTissue DonorsCLU protein, humanClusterinSP1 protein, humanSp1 Transcription FactorSP3 protein, humanSp3 Transcription FactorTranscription Factor AP-13D corneal modelActivator Protein 1 (AP1)clusterinhuman corneapromoterSpecific protein 1 and 3 (Sp1/Sp3)tissue-engineeringtranscription factorwound healing

Identifiers

PMID34830308
PMCPMC8621254
OpenAlexW3212470820

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.