Evidence map›Paper›PMID 34830313›Full record

ArticleInternational journal of molecular sciences2021

Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo-

Russell R Fling, Timothy R Zacharewski

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Russell R FlingDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-9332-0876
Timothy R ZacharewskiInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA.
Michigan State University · US

Funding

VOLATILE ORGANIC CONTAMINANTS--QUANTIFYING THEIR MOVEMENT IN THE UNSATURATED ZONEP42ES004911 · NIEHS · MICHIGAN STATE UNIVERSITY · PI Brian P. Johnson · 1989 to 2026
$64.9M
MULTIDISCIPLINARY TRAINING IN ENVIRONMENTAL TOXICOLOGYT32ES007255 · NIEHS · MICHIGAN STATE UNIVERSITY · PI JOHN J LAPRES · 1989 to 2026
$9.3M
AhR-dependent Pkm2 regulation in NAFLD progressionR01ES029541 · NIEHS · MICHIGAN STATE UNIVERSITY · PI ZACHAREWSKI, TIMOTHY R. · 2019 to 2023
$1.9M
NIEHS NIH HHS P42 ES004911NIEHS NIH HHS P42ES004911NIEHS NIH HHS R01 ES029541NIEHS NIH HHS R01ES029541NIEHS NIH HHS T32ES00725NIEHS NIH HHS T32 ES007255The AgBioResearch at Michigan State University MICL02603
6 · The paper itself

Abstract

Gut dysbiosis with disrupted enterohepatic bile acid metabolism is commonly associated with non-alcoholic fatty liver disease (NAFLD) and recapitulated in a NAFLD-phenotype elicited by 2,3,7,8-tetrachlorodibenzo-

Indexed as

AnimalsBacteroidetesBasic Helix-Loop-Helix ProteinsDysbiosisGastrointestinal MicrobiomeGene Expression RegulationHumansLactobacillusLiverLiver CirrhosisMaleMetabolic Networks and PathwaysMiceMice, Inbred C57BLNon-alcoholic Fatty Liver DiseasePolychlorinated DibenzodioxinsAHR protein, humanAhr protein, mouseBasic Helix-Loop-Helix ProteinsPolychlorinated DibenzodioxinsReceptors, Aryl Hydrocarbon2,3,7,8-tetrachlorodibenzo-p-dioxinaryl hydrocarbon receptordioxinfibrosisgut dysbiosisgut microbiomenon-alcoholic fatty liver diseasesecondary bile acids

Identifiers

PMID34830313
PMCPMC8625315
OpenAlexW3213893120

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.