Evidence map›Paper›PMID 34830337›Full record

ReviewInternational journal of molecular sciences2021

Significance of GABA

Yuya Sakimoto, Paw Min-Thein Oo, Makoto Goshima, Itsuki Kanehisa, Yutaro Tsukada, Dai Mitsushima

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 75 citations in OpenAlex.

  1. Trial
  2. Review
  3. [Extracellular matrix materials and tissue regeneration and repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Massive Activation of GABABiomolecules · 2025
    Review
  9. Phosphorylation of GABAScientific reports · 2025
    Article
  10. Review
  11. Review
  12. Article
  13. Sex-Dependent Modulation of AMPA and GABACurrent neuropharmacology · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yuya SakimotoDepartment of Physiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
Paw Min-Thein OoDepartment of Physiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
Makoto GoshimaDepartment of Physiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
Itsuki KanehisaDepartment of Physiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
Yutaro TsukadaDepartment of Physiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
Dai MitsushimaDepartment of Physiology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.
Yamaguchi University · JP

Funding

Ministry of Education, Culture, Sports, Science, and Technology of Japan 20K07276
6 · The paper itself

Abstract

The hippocampus is a primary area for contextual memory, known to process spatiotemporal information within a specific episode. Long-term strengthening of glutamatergic transmission is a mechanism of contextual learning in the dorsal cornu ammonis 1 (CA1) area of the hippocampus. CA1-specific immobilization or blockade of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptor delivery can impair learning performance, indicating a causal relationship between learning and receptor delivery into the synapse. Moreover, contextual learning also strengthens GABA

Indexed as

Alzheimer DiseaseAnimalsAutism Spectrum DisorderCA1 Region, HippocampalCognitionEpilepsyGene Expression RegulationHumansLearningNeuronal PlasticityNeuronsNootropic AgentsProtein TransportReceptors, AMPAReceptors, GABA-ASynapsesNootropic AgentsReceptors, AMPAReceptors, GABA-AAMPA receptorcontextual learningGABAA receptorsynaptic plasticity

Identifiers

PMID34830337
PMCPMC8623595
OpenAlexW3211958465

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.