Evidence map›Paper›PMID 34830353›Full record

ArticleInternational journal of molecular sciences2021

Mediation of the Cardioprotective Effects of Mannitol Discovered, with Refutation of Common Protein Kinases.

Carolin Torregroza, Chiara O Glashoerster, Katharina Feige, Martin Stroethoff, Annika Raupach, André Heinen, Markus W Hollmann, Ragnar Huhn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Carolin TorregrozaDepartment of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.
Chiara O GlashoersterDepartment of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.
Katharina FeigeDepartment of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.
Martin StroethoffDepartment of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.
Annika RaupachDepartment of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.ORCID 0000-0001-5257-1022
André HeinenInstitute of Cardiovascular Physiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany.
Markus W HollmannDepartment of Anesthesiology, Amsterdam University Medical Center (AUMC), Location AMC, Meiberdreef 9, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0001-8248-0244
Ragnar HuhnDepartment of Anesthesiology, Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf, Moorenstr. 5, 40225 Duesseldorf, Germany.
Düsseldorf University Hospital · DEAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The osmodiuretic agent Mannitol exerts cardioprotection against ischemia and reperfusion (I/R) injury when applied as a pre- and/or postconditioning stimulus. Previously, we demonstrated that these properties are mediated via the activation of mitochondrial ATP-sensitive potassium (mK

Indexed as

AnimalsCarbazolesCyclic GMP-Dependent Protein KinasesHeartHeterocyclic Compounds, 3-RingHumansIschemic Preconditioning, MyocardialKATP ChannelsKidneyMannitolMyocardial Reperfusion InjuryMyocardiumNitric Oxide Synthase Type IIIProto-Oncogene Proteins c-aktRatsReceptor, Adenosine A11,3-dipropyl-8-cyclopentylxanthineAkt1 protein, ratCarbazolesCyclic GMP-Dependent Protein KinasesHeterocyclic Compounds, 3-RingKATP ChannelsKT 5823MannitolMK 2206Nitric Oxide Synthase Type IIINos3 protein, ratProto-Oncogene Proteins c-aktReceptor, Adenosine A1Xanthinesadenosine receptormannitolmyocardial infarctionpreconditioningprotein kinase Bprotein kinase G

Identifiers

PMID34830353
PMCPMC8625521
OpenAlexW3213427345

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.