Evidence map›Paper›PMID 34830371›Full record

ArticleInternational journal of molecular sciences2021

Repurposing Riociguat to Target a Novel Paracrine Nitric Oxide-TRPC6 Pathway to Prevent Podocyte Injury.

Daan 't Hart, Jinhua Li, Johan van der Vlag, Tom Nijenhuis

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Daan 't HartDepartment of Nephrology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-2718-9432
Jinhua LiDepartment of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia.
Johan van der VlagDepartment of Nephrology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0001-7843-5918
Tom NijenhuisDepartment of Nephrology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-4375-7236
Radboud University Nijmegen · NLMonash University · AU

Funding

Nierstichting 13OKS023 and 19OP023
6 · The paper itself

Abstract

Increased expression and activity of the Ca

Indexed as

AnimalsCalcium SignalingCyclic GMPDrug RepositioningEndothelial CellsGuanylate CyclaseHumansKidney DiseasesKidney GlomerulusMiceNitric OxideParacrine CommunicationPodocytesPyrazolesPyrimidinesTRPC6 Cation ChannelCyclic GMPGuanylate CyclaseNitric OxidePyrazolesPyrimidinesriociguatTRPC6 Cation Channelfocal segmental glomerulosclerosisnitric oxidepodocyte injuryRiociguatTRPC6

Identifiers

PMID34830371
PMCPMC8621407
OpenAlexW3216808139

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.