Evidence map›Paper›PMID 34830774›Full record

ReviewCancers2021

Lipid Nanocarriers for Hyperproliferative Skin Diseases.

Eliana B Souto, Ana L R de Souza, Fernanda K Dos Santos, Elena Sanchez-Lopez, Amanda Cano, Aleksandra Zielińska, Rafał Staszewski, Jacek Karczewski, Maria P D Gremião, Marlus Chorilli

Abstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eliana B SoutoCEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.ORCID 0000-0002-9737-6017
Ana L R de SouzaFaculty of Pharmaceutical Sciences, São Paulo State University (UNESP), Campus of Araraquara, Rodovia Araraquara Jaú, Araraquara 14800-903, SP, Brazil.
Fernanda K Dos SantosFaculty of Pharmaceutical Sciences, São Paulo State University (UNESP), Campus of Araraquara, Rodovia Araraquara Jaú, Araraquara 14800-903, SP, Brazil.
Elena Sanchez-LopezDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08007 Barcelona, Spain.ORCID 0000-0003-2571-108X
Amanda CanoDepartment of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08007 Barcelona, Spain.ORCID 0000-0001-9567-4283
Aleksandra ZielińskaInstitute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland.ORCID 0000-0003-2603-1377
Rafał StaszewskiDepartment of Hypertension Angiology and Internal Medicine, Poznań University of Medical Sciences, 61-701 Poznań, Poland.
Jacek KarczewskiDepartment of Environmental Medicine, Poznań University of Medical Sciences, 61-701 Poznań, Poland.ORCID 0000-0002-8322-4186
Maria P D GremiãoFaculty of Pharmaceutical Sciences, São Paulo State University (UNESP), Campus of Araraquara, Rodovia Araraquara Jaú, Araraquara 14800-903, SP, Brazil.
Marlus ChorilliFaculty of Pharmaceutical Sciences, São Paulo State University (UNESP), Campus of Araraquara, Rodovia Araraquara Jaú, Araraquara 14800-903, SP, Brazil.ORCID 0000-0002-6698-0545

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so diverse, including 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, realgar, and corticosteroids in general. These drugs usually have low aqueous solubility, which consequently decreases skin permeation. Thus, their incorporation in lipid nanocarriers has been proposed with the main objective to increase the effectiveness of topical treatment and reduce side effects. This manuscript aims to describe the advantages of using lipid nanoparticles and liposomes that can be used to load diversity of chemically different drugs for the treatment of HSD.

Indexed as

antiproliferative drugshyperproliferative skin diseaseslipid nanoparticlesliposomesskin cancer

Identifiers

PMID34830774
PMCPMC8615830

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.