Evidence map›Paper›PMID 34830809›Full record

ArticleCancers2021

Transcriptional and Mutational Profiling of B-Other Acute Lymphoblastic Leukemia for Improved Diagnostics.

Philippe Chouvarine, Željko Antić, Jana Lentes, Charlotte Schröder, Julia Alten, Monika Brüggemann, Enrique Carrillo-de Santa Pau, Thomas Illig, Teresa Laguna, Denis Schewe and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Philippe ChouvarineInstitute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Željko AntićInstitute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.ORCID 0000-0001-9398-2637
Jana LentesInstitute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Charlotte SchröderInstitute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Julia AltenBerlin-Frankfurt-Münster ALL Study Group Germany (BFM-G), Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Monika BrüggemannDepartment of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Enrique Carrillo-de Santa PauComputational Biology Group, Precision Nutrition and Cancer Research Program, IMDEA Food Institute, 28049 Madrid, Spain.ORCID 0000-0002-2310-2267
Thomas IlligInstitute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Teresa LagunaComputational Biology Group, Precision Nutrition and Cancer Research Program, IMDEA Food Institute, 28049 Madrid, Spain.
Denis ScheweBerlin-Frankfurt-Münster ALL Study Group Germany (BFM-G), Department of Pediatrics, University Medical Center Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.ORCID 0000-0002-1070-0217
Martin StanullaPediatric Hematology and Oncology, Hannover Medical School (MHH), 30625 Hannover, Germany.
Ming TangInstitute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Martin ZimmermannPediatric Hematology and Oncology, Hannover Medical School (MHH), 30625 Hannover, Germany.
Martin SchrappeDepartment of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Brigitte SchlegelbergerInstitute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Gunnar CarioDepartment of Hematology, University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
Anke K BergmannInstitute of Human Genetics, Hannover Medical School (MHH), 30625 Hannover, Germany.
Medizinische Hochschule Hannover · DEUniversity Hospital Schleswig-Holstein · DEMadrid Institute for Advanced Studies · ES

Funding

Deutsche Forschungsgemeinschaft BE6555/1-1Deutsche Forschungsgemeinschaft BE6555/2-1
6 · The paper itself

Abstract

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common cancer in children, and significant progress has been made in diagnostics and the treatment of this disease based on the subtypes of BCP-ALL. However, in a large proportion of cases (B-other), recurrent BCP-ALL-associated genomic alterations remain unidentifiable by current diagnostic procedures. In this study, we performed RNA sequencing and analyzed gene fusions, expression profiles, and mutations in diagnostic samples of 185 children with BCP-ALL. Gene expression clustering showed that a subset of B-other samples partially clusters with some of the known subgroups, particularly

Indexed as

B-cell precursor acute lymphoblastic leukemiagene fusionstreatment stratification biomarkerswhole-transcriptome sequencing

Identifiers

PMID34830809
PMCPMC8616234
OpenAlexW3213216708

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.