Evidence map›Paper›PMID 34830902›Full record

ReviewCancers2021

Molecular Markers to Predict Prognosis and Treatment Response in Uterine Cervical Cancer.

Maximilian Fleischmann, Georgios Chatzikonstantinou, Emmanouil Fokas, Jörn Wichmann, Hans Christiansen, Klaus Strebhardt, Claus Rödel, Nikolaos Tselis, Franz Rödel

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

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  7. LncRNAiScience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maximilian FleischmannDepartment of Radiation Oncology, University Hospital Johann Wolfgang Goethe University, 60590 Frankfurt, Germany.
Georgios ChatzikonstantinouDepartment of Radiation Oncology, University Hospital Johann Wolfgang Goethe University, 60590 Frankfurt, Germany.
Emmanouil FokasDepartment of Radiation Oncology, University Hospital Johann Wolfgang Goethe University, 60590 Frankfurt, Germany.
Jörn WichmannInstitute for Radiation Therapy and Special Oncology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0001-5575-8933
Hans ChristiansenInstitute for Radiation Therapy and Special Oncology, Hannover Medical School, 30625 Hannover, Germany.
Klaus StrebhardtGerman Cancer Consortium (DKTK), Partner Site Frankfurt am Main, 60590 Frankfurt, Germany.ORCID 0000-0003-2173-9763
Claus RödelDepartment of Radiation Oncology, University Hospital Johann Wolfgang Goethe University, 60590 Frankfurt, Germany.
Nikolaos TselisDepartment of Radiation Oncology, University Hospital Johann Wolfgang Goethe University, 60590 Frankfurt, Germany.
Franz RödelDepartment of Radiation Oncology, University Hospital Johann Wolfgang Goethe University, 60590 Frankfurt, Germany.ORCID 0000-0001-6057-1022
Goethe University Frankfurt · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uterine cervical cancer is one of the leading causes of cancer-related mortality in women worldwide. Each year, over half a million new cases are estimated, resulting in more than 300,000 deaths. While less-invasive, fertility-preserving surgical procedures can be offered to women in early stages, treatment for locally advanced disease may include radical hysterectomy, primary chemoradiotherapy (CRT) or a combination of these modalities. Concurrent platinum-based chemoradiotherapy regimens remain the first-line treatments for locally advanced cervical cancer. Despite achievements such as the introduction of angiogenesis inhibitors, and more recently immunotherapies, the overall survival of women with persistent, recurrent or metastatic disease has not been extended significantly in the last decades. Furthermore, a broad spectrum of molecular markers to predict therapy response and survival and to identify patients with high- and low-risk constellations is missing. Implementation of these markers, however, may help to further improve treatment and to develop new targeted therapies. This review aims to provide comprehensive insights into the complex mechanisms of cervical cancer pathogenesis within the context of molecular markers for predicting treatment response and prognosis.

Indexed as

biomarkercervical cancerchemoradiotherapymolecular markeroutcomepredictiveprognosticresponsesurvival

Identifiers

PMID34830902
PMCPMC8616420
OpenAlexW3211569206

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.