Evidence map›Paper›PMID 34831101›Full record

ReviewCells2021

Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy.

Aditya Bhalerao, Snehal Raut, Behnam Noorani, Salvatore Mancuso, Luca Cucullo

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Observational
  5. COVID-19 inflammation and implications in drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2022
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Aditya BhaleraoDepartment of Biological and Biomedical Sciences, Oakland University, Rochester, MI 48309, USA.
Snehal RautDepartment of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USA.ORCID 0000-0001-8550-7684
Behnam NooraniDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.
Salvatore MancusoDepartment of Biological and Biomedical Sciences, Oakland University, Rochester, MI 48309, USA.
Luca CuculloDepartment of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USA.ORCID 0000-0002-2827-7162
Oakland University · USTexas Tech University · US

Funding

Testing tobacco smoke toxicity at the blood-brain barrierR01DA029121 · NIDA · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI ABBRUSCATO, THOMAS J, CUCULLO, LUCA · 2011 to 2021
$3.6M
Repurposing Metformin to Offset Stroke Risk and Injury in Comorbid Populations of SmokersR01NS117906 · NINDS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI ABBRUSCATO, THOMAS J, CUCULLO, LUCA · 2020 to 2024
$2.9M
Blood and Brain Based Biomarkers of Injury to Assess the Cerebrovascular Impact of Emerging Alternatives to Classic Cigarette ProductsR01DA049737 · NIDA · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI ABBRUSCATO, THOMAS J, CUCULLO, LUCA · 2019 to 2021
$1.4M
NIDA NIH HHS 1R01DA049737NIDA NIH HHS 2R01DA029121NINDS NIH HHS 1R01NS117906
6 · The paper itself

Abstract

As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests itself in the form of severe respiratory distress, it is also known to cause systemic damage to almost all major organs and organ systems within the body. In this review, we discuss the molecular mechanisms leading to multi-organ failure seen in COVID-19 patients. We also examine the potential of stem cell therapy in treating COVID-19 multi-organ failure cases.

Indexed as

Stem Cell TransplantationClinical Trials as TopicCOVID-19Cytokine Release SyndromeHumansImmunomodulationMultiple Organ FailureRegenerative MedicineSARS-CoV-2Stem Cellsblood-brain-barrierCOVID-19mesenchymaloxidative stressregenerativeSARS-CoV-2stem cellstherapeutics

Identifiers

PMID34831101
PMCPMC8616204
OpenAlexW3209346717

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.