Evidence map›Paper›PMID 34831199›Full record

ArticleCells2021

Integrative Analyses Reveal

Adi Zheng, Hao Li, Zhihui Feng, Jiankang Liu

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Association betweenBiomedical reports · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Adi ZhengDepartment of Biomedical Sciences, University of Lausanne, Bugnon 7, 1005 Lausanne, Switzerland.
Hao LiCenter for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Zhihui FengCenter for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.ORCID 0000-0002-2448-6565
Jiankang LiuCenter for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Xi'an Jiaotong University · CNQingdao University · CNUniversity of Lausanne · CH

Funding

National Natural Science Foundation of China 31570777National Natural Science Foundation of China 31770917National Natural Science Foundation of China 32071154National Natural Science Foundation of China 81571050National Natural Science Foundation of China 91649106
6 · The paper itself

Abstract

High-density lipoprotein (HDL) cholesterol levels are closely associated with human health and diseases. To identify genes modulating plasma HDL levels, we integrated HDL measurements and multi-omics data collected from diverse mouse cohorts and combined a list of systems genetics methods, including quantitative trait loci (QTL) mapping analysis, mediation analysis, transcriptome-wide association analysis (TWAS), and correlation analysis. We confirmed a significant and conserved QTL for plasma HDL on chromosome 1 and identified that

Indexed as

AnimalsBiomarkersCholesterol, HDLDatabases as TopicDietFemaleGene Expression ProfilingGene Expression RegulationMaleMiceMice, Inbred C57BLMitochondriaNeoplasm ProteinsProteomeQuantitative Trait LociRNA, MessengerBiomarkersCholesterol, HDLNeoplasm ProteinsProteomeRNA, MessengerThiosulfate SulfurtransferaseTstd1 protein, mousecorrelation analysisHDLintegrative analysismediation analysismitochondriaquantitative trait loci (QTL)systems geneticstranscriptome-wide association analysis (TWAS)

Identifiers

PMID34831199
PMCPMC8616306
OpenAlexW3208163188

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.