Evidence map›Paper›PMID 34831221›Full record

ArticleCells2021

Regulation of Transplanted Cell Homing by FGF1 and PDGFB after Doxorubicin Myocardial Injury.

Mark Baguma-Nibasheka, Tiam Feridooni, Feixiong Zhang, Kishore B S Pasumarthi

Abstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Cardiac fibrosis in oncologic therapies.Current opinion in physiology · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mark Baguma-NibashekaDepartment of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Tiam FeridooniDepartment of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada.ORCID 0000-0002-9480-9737
Feixiong ZhangDepartment of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Kishore B S PasumarthiDepartment of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada.ORCID 0000-0001-9317-076X

Funding

Heart and Stroke Foundation of Canada G-18-0022140
6 · The paper itself

Abstract

There is no effective treatment for the total recovery of myocardial injury caused by an anticancer drug, doxorubicin (Dox). In this study, using a Dox-induced cardiac injury model, we compared the cardioprotective effects of ventricular cells harvested from 11.5-day old embryonic mice (E11.5) with those from E14.5 embryos. Our results indicate that tail-vein-infused E11.5 ventricular cells are more efficient at homing into the injured adult myocardium, and are more angiogenic, than E14.5 ventricular cells. In addition, E11.5 cells were shown to mitigate the cardiomyopathic effects of Dox. In vitro, E11.5 ventricular cells were more migratory than E14.5 cells, and RT-qPCR analysis revealed that they express significantly higher levels of cytokine receptors

Indexed as

Cell TransplantationAgingAnimalsCell MovementDoxorubicinElectrocardiographyEmbryo, MammalianFibroblast Growth Factor 1Gene Expression RegulationHeart VentriclesMiceMice, Inbred C57BLMyocardiumNeovascularization, PhysiologicProto-Oncogene Proteins c-sisReceptors, ChemokineDoxorubicinFibroblast Growth Factor 1Proto-Oncogene Proteins c-sisReceptors, ChemokineRNA, Messengercardiac dysfunctioncardiomyopathydoxorubicingrowth factor and chemokine receptorsventricular cell migration

Identifiers

PMID34831221
PMCPMC8616453

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.