Evidence map›Paper›PMID 34831283›Full record

ArticleCells2021

NSC828779 Alleviates Renal Tubulointerstitial Lesions Involving Interleukin-36 Signaling in Mice.

Shin-Ruen Yang, Szu-Chun Hung, Lichieh Julie Chu, Kuo-Feng Hua, Chyou-Wei Wei, I-Lin Tsai, Chih-Chin Kao, Chih-Chien Sung, Pauling Chu, Chung-Yao Wu and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Generalized Pustular Psoriasis and Systemic Organ Dysfunctions.International journal of molecular sciences · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Shin-Ruen YangDepartment of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Szu-Chun HungDivision of Nephrology, Taipei Tzu Chi Hospital, Taipei 23142, Taiwan.
Lichieh Julie ChuMolecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan.
Kuo-Feng HuaDepartment of Biotechnology and Animal Science, National Ilan University, Ilan 260007, Taiwan.
Chyou-Wei WeiDepartment of Nutrition, Master Program of Biomedical Nutrition, Hungkuang University, Taichung 433304, Taiwan.
I-Lin TsaiDepartment of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-3951-5197
Chih-Chin KaoDivision of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 11031, Taiwan.
Chih-Chien SungDivision of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Pauling ChuDivision of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.ORCID 0000-0002-4221-5152
Chung-Yao WuDepartment of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Ann ChenDepartment of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Alexander T H WuThe PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-0178-6530
Feng-Cheng LiuDivision of Rheumatology/Immunology and Allergy, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Hsu-Shan HuangGraduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11301, Taiwan.
Shuk-Man KaGraduate Institute of Aerospace and Undersea Medicine, Department of Medicine, National Defense Medical Center, Taipei 11490, Taiwan.
Tri-Service General Hospital · TWTaipei Medical University · TWChang Gung University · TWChina Medical University · TWHungkuang University · TWNational Defense Medical Center · TWTaipei Medical University Hospital · TWTaipei Tzu Chi Hospital · TW

Funding

Ministry of Science and Technology 109-2314-B-016-034-MY3Ministry of Science and Technology 109-2320-B-016-008National Defense Medical Center MAB-109-028Tri-Service General Hospital, Taipei, Taiwan. TSGH-D-109090
6 · The paper itself

Abstract

Renal tubulointerstitial lesions (TILs), a common pathologic hallmark of chronic kidney disease that evolves to end-stage renal disease, is characterized by progressive inflammation and pronounced fibrosis of the kidney. However, current therapeutic approaches to treat these lesions remain largely ineffectual. Previously, we demonstrated that elevated IL-36α levels in human renal tissue and urine are implicated in impaired renal function, and IL-36 signaling enhances activation of NLRP3 inflammasome in a mouse model of TILs. Recently, we synthesized NSC828779, a salicylanilide derivative (protected by U.S. patents with US 8975255 B2 and US 9162993 B2), which inhibits activation of NF-κB signaling with high immunomodulatory potency and low IC

Indexed as

Signal TransductionAnimalsCell LineCytokinesDisease Models, AnimalEpithelial CellsFemaleHydrogen PeroxideInflammasomesInterleukin-1LipopolysaccharidesMacrophagesMiceMice, Inbred C57BLMolecular Docking SimulationNephritis, InterstitialCytokinesHydrogen PeroxideInflammasomesInterleukin-1interleukin-36, mouseLipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinsalicylanilideSalicylanilidesSTAT3 Transcription FactorIL-36αIL-36α/NLRP3 inflammasomemechanically induced constant pressuresalicylanilide derivativetubulointerstitial lesions

Identifiers

PMID34831283
PMCPMC8623783
OpenAlexW3213525014

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.