Evidence map›Paper›PMID 34831329›Full record

ArticleCells2021

Phosphoprotein Phosphatase 1 but Not 2A Activity Modulates Coupled-Clock Mechanisms to Impact on Intrinsic Automaticity of Sinoatrial Nodal Pacemaker Cells.

Syevda Tagirova Sirenko, Ihor Zahanich, Yue Li, Yevgeniya O Lukyanenko, Alexey E Lyashkov, Bruce D Ziman, Kirill V Tarasov, Antoine Younes, Daniel R Riordon, Yelena S Tarasova and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Emerging Regulatory Mechanisms in Sinoatrial Node Automaticity.Journal of cellular and molecular medicine · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Compartmentalized cAMP signalling and control of cardiac rhythm.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  7. Role of Dopamine in the Heart in Health and Disease.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Syevda Tagirova SirenkoLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Ihor ZahanichLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Yue LiLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Yevgeniya O LukyanenkoLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.ORCID 0000-0003-2096-2971
Alexey E LyashkovLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Bruce D ZimanLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Kirill V TarasovLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Antoine YounesLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Daniel R RiordonLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Yelena S TarasovaLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Dongmei YangLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Tatiana M VinogradovaLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Victor A MaltsevLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.ORCID 0000-0002-3832-791X
Edward G LakattaLaboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
National Institute on Aging · US

Funding

Intramural Research Program of National Institute on Aging, NIH, USA NA
6 · The paper itself

Abstract

Spontaneous AP (action potential) firing of sinoatrial nodal cells (SANC) is critically dependent on protein kinase A (PKA) and Ca

Indexed as

Biological ClocksAction PotentialsAnimalsCalciumCalcium-Binding ProteinsCalcium Channels, L-TypeCell Membrane PermeabilityComputer SimulationCyclic AMP-Dependent Protein KinasesHeart VentriclesMarine ToxinsModels, BiologicalOxazolesPhospholambanPhosphoprotein PhosphatasesPhosphorylationCalciumCalcium-Binding ProteinsCalcium Channels, L-Typecalyculin ACyclic AMP-Dependent Protein KinasesMarine ToxinsOxazolesPhospholambanPhosphoprotein PhosphatasesRNA, Messengercalyculin Aendogenous phosphatase inhibitorslocal Ca2+ releasesL-type Ca2+ channelsnumerical modelokadaic acidphospholambanphosphoprotein phosphataseryanodine receptorssinoatrial node cells

Identifiers

PMID34831329
PMCPMC8623309
OpenAlexW3211892536

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.