Evidence map›Paper›PMID 34834134›Full record

ReviewMolecules (Basel, Switzerland)2021

Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine.

David T Wu, Jose G Munguia-Lopez, Ye Won Cho, Xiaolu Ma, Vivian Song, Zhiyue Zhu, Simon D Tran

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Driving emerging technology to clinical impact.Journal of the American Dental Association (1939) · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Special Issue "Synthesis, Properties and Applications of Polymers".International journal of molecular sciences · 2025
    Article
  19. Article
  20. The rising potential of tooth germ-derived stem cells and the future of oral rehabilitation.Journal of advanced periodontology & implant dentistry · 2025
    Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David T WuCraniofacial Stem Cells and Tissue Engineering Laboratory, Faculty of Dentistry, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0002-9752-5377
Jose G Munguia-LopezCraniofacial Stem Cells and Tissue Engineering Laboratory, Faculty of Dentistry, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0002-5173-6494
Ye Won ChoDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Harvard University, Boston, MA 02115, USA.ORCID 0000-0002-1502-2195
Xiaolu MaCraniofacial Stem Cells and Tissue Engineering Laboratory, Faculty of Dentistry, McGill University, Montreal, QC H3A 0C7, Canada.
Vivian SongCraniofacial Stem Cells and Tissue Engineering Laboratory, Faculty of Dentistry, McGill University, Montreal, QC H3A 0C7, Canada.
Zhiyue ZhuDepartment of Bioengineering, Faculty of Engineering, McGill University, Montreal, QC H3A 0E9, Canada.ORCID 0000-0002-2182-6712
Simon D TranCraniofacial Stem Cells and Tissue Engineering Laboratory, Faculty of Dentistry, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0001-5594-359X

Funding

Natural Sciences and Engineering Research Council RGPIN-2017-05247
6 · The paper itself

Abstract

Dental, oral, and craniofacial (DOC) regenerative medicine aims to repair or regenerate DOC tissues including teeth, dental pulp, periodontal tissues, salivary gland, temporomandibular joint (TMJ), hard (bone, cartilage), and soft (muscle, nerve, skin) tissues of the craniofacial complex. Polymeric materials have a broad range of applications in biomedical engineering and regenerative medicine functioning as tissue engineering scaffolds, carriers for cell-based therapies, and biomedical devices for delivery of drugs and biologics. The focus of this review is to discuss the properties and clinical indications of polymeric scaffold materials and extracellular matrix technologies for DOC regenerative medicine. More specifically, this review outlines the key properties, advantages and drawbacks of natural polymers including alginate, cellulose, chitosan, silk, collagen, gelatin, fibrin, laminin, decellularized extracellular matrix, and hyaluronic acid, as well as synthetic polymers including polylactic acid (PLA), polyglycolic acid (PGA), polycaprolactone (PCL), poly (ethylene glycol) (PEG), and Zwitterionic polymers. This review highlights key clinical applications of polymeric scaffolding materials to repair and/or regenerate various DOC tissues. Particularly, polymeric materials used in clinical procedures are discussed including alveolar ridge preservation, vertical and horizontal ridge augmentation, maxillary sinus augmentation, TMJ reconstruction, periodontal regeneration, periodontal/peri-implant plastic surgery, regenerative endodontics. In addition, polymeric scaffolds application in whole tooth and salivary gland regeneration are discussed.

Indexed as

Regenerative MedicineTissue ScaffoldsBiocompatible MaterialsHumansBiocompatible Materialsbone regenerationperiodontal regenerationpolymeric scaffoldspolymerspulp regenerationregenerative medicinesalivary gland regenerationsinus augmentationtissue engineeringwhole tooth regeneration

Identifiers

PMID34834134
PMCPMC8621873

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.