ArticleMolecules (Basel, Switzerland)2021
Solubility of Cinnarizine in (Transcutol + Water) Mixtures: Determination, Hansen Solubility Parameters, Correlation, and Thermodynamics.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Design and Optimization of Self-Nanoemulsifying Drug Delivery Systems to Enhance the Anti-Inflammatory Efficacy ofPharmaceutics · 2026Article
- Wet Granulation as a Solidification Strategy for Converting Aqueous Nanosuspensions into Solid Dosage Forms.Pharmaceutics · 2026Article
- Predicting Solubility Enhancement ofMolecules (Basel, Switzerland) · 2026Article
- Evaluating the Impact of Intestinal Bile Salts on Drug Absorption Using PBPK Modeling: Case Studies With Efavirenz, Cinnarizine, and Posaconazole.CPT: pharmacometrics & systems pharmacology · 2026Article
- Supramolecular Organogels Based on Cinnarizine as a Potential Gastroretentive System: In Vitro and In Silico Simulations.Gels (Basel, Switzerland) · 2026Article
- Solubility and thermodynamic analysis of aceclofenac in different {Carbitol + water} mixtures at various temperatures.BMC chemistry · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Between 293.2 and 313.2 K and at 0.1 MPa, the solubility of the weak base, cinnarizine (CNZ) (3), in various {Transcutol-P (TP) (1) + water (2)} combinations is reported. The Hansen solubility parameters (HSP) of CNZ and various {(TP) (1) + water (2)} mixtures free of CNZ were also predicted using HSPiP software. Five distinct cosolvency-based mathematical models were used to link the experimentally determined solubility data of CNZ. The solubility of CNZ in mole fraction was increased with elevated temperature and TP mass fraction in {(TP) (1) + water (2)} combinations. The maximum solubility of CNZ in mole fraction was achieved in neat TP (5.83 × 10
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Registered trials
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