Evidence map›Paper›PMID 34834394›Full record

ArticlePharmaceutics2021

A Combination Approach in Inhibiting Type 2 Diabetes-Related Enzymes Using

Blessing Mabate, Chantal Désirée Daub, Samkelo Malgas, Adrienne Lesley Edkins, Brett Ivan Pletschke

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Bioactive properties of fucoidan from Malaysian brown seaweed (Journal of food science and technology · 2026
    Article
  3. Review
  4. Article
  5. Foods (Basel, Switzerland) · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Blessing MabateEnzyme Science Programme (ESP), Department of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0002-3584-5703
Chantal Désirée DaubEnzyme Science Programme (ESP), Department of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0001-7914-6229
Samkelo MalgasDepartment of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria 0028, South Africa.ORCID 0000-0003-0729-5393
Adrienne Lesley EdkinsBiomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0002-3615-6651
Brett Ivan PletschkeEnzyme Science Programme (ESP), Department of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Makhanda 6140, South Africa.ORCID 0000-0001-8117-1730
Rhodes University · ZAUniversity of Pretoria · ZA

Funding

German Academic Exchange Service 57408782Henderson Scholarship Chantal DaubKelpX Brett PletschkeNational Research Foundation 116951National Research Foundation 98566 and 105829Pearson and Young Memorial Scholarship Chantal DaubRhodes University Adirenne Edkins and Brett PletschkeUniversity of Pretoria Samkelo Malgas
6 · The paper itself

Abstract

Although there are chemotherapeutic efforts in place for Type 2 diabetes mellitus (T2DM), there is a need for novel strategies (including natural products) to manage T2DM. Fucoidan, a sulphated polysaccharide was extracted from

Indexed as

acarbosecombination approachEcklonia radiatafucoidantype 2 diabetes management

Identifiers

PMID34834394
PMCPMC8619669
OpenAlexW3217420353

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.