Evidence mapPaperPMID 34835935Full record

ArticleNutrients2021

Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents.

Fatme Al-Anouti, Mira Mousa, Spyridon N Karras, William B Grant, Zainab Alhalwachi, Laila Abdel-Wareth, Maimunah Uddin, Nawal Alkaabi, Guan K Tay, Bassam Mahboub and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. The role of vitamin D receptor and IL-6 in COVID-19.Molecular genetics & genomic medicine · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Essential metals, vitamins and antioxidant enzyme activities in COVID-19 patients and their potential associations with the disease severity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. The association ofEXCLI journal · 2022
    Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 5 countries.

Fatme Al-AnoutiDepartment of Health Sciences, College of Natural and Health Sciences, Zayed University, Abu Dhabi, United Arab Emirates.ORCID 0000-0002-1993-6656
Mira MousaNuffield Department of Women's and Reproductive Health, Oxford University, Oxford OX1 4BH, UK.
Spyridon N KarrasNational Scholarship Foundation, 55535 Thessaloniki, Greece.ORCID 0000-0002-4225-2746
William B GrantSunlight, Nutrition and Health Research Center, San Francisco, CA 94164-1603, USA.ORCID 0000-0002-1439-3285
Zainab AlhalwachiCenter for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.ORCID 0000-0001-6501-7055
Laila Abdel-WarethNational Reference Laboratory, Abu Dhabi, United Arab Emirates.
Maimunah UddinDepartment of Pediatric Infectious Disease, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.ORCID 0000-0002-1175-4145
Nawal AlkaabiDepartment of Pediatric Infectious Disease, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.
Guan K TayCenter for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Bassam MahboubDubai Health Authority, Rashid Hospital, Dubai, United Arab Emirates.
Habiba AlSafarCenter for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.ORCID 0000-0001-7141-1438
Khalifa University of Science and Technology · AEShaikh Khalifa Medical City · AEAbu Dhabi National Oil (United Arab Emirates) · AEDubai Health Authority · AEEdith Cowan University · AUFrontier Science Foundation-Hellas · GRSunlight Nutrition and Health Research Center · USZayed University · AE

Funding

Khalifa University of Science and Technology COVID19004Zayed University 004
6 · The paper itself

Abstract

Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (

Indexed as

Polymorphism, Single NucleotideAdultBiomarkersCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCholestanetriol 26-MonooxygenaseCOVID-19Cytochrome P450 Family 2FemaleHumansMaleMiddle AgedReceptors, CalcitriolSeverity of Illness IndexUnited Arab EmiratesVitamin D25-hydroxyvitamin DBiomarkersCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCholestanetriol 26-MonooxygenaseCYP2R1 protein, humanCytochrome P450 Family 2NADSYN1 protein, humanReceptors, CalcitriolVDR protein, humanVitamin DCOVID-19genotypesmetabolismpolymorphismUAEvitamin D

Identifiers

PMID34835935
PMCPMC8625365
OpenAlexW3205951788

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.