Evidence mapPaperPMID 34835953Full record

Trial reportNutrients2021

Time-Limited Eating and Continuous Glucose Monitoring in Adolescents with Obesity: A Pilot Study.

Alaina P Vidmar, Monica Naguib, Jennifer K Raymond, Sarah Jeanne Salvy, Elizabeth Hegedus, Choo Phei Wee, Michael I Goran

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 6 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  3. [Research Advancements in Gastric Capacity Intervention for Childhood and Adolescent Obesity].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
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  10. Impact of 8-hour time-limited eating on sleep in adolescents with obesity.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alaina P VidmarCenter for Endocrinology, Diabetes and Metabolism, Diabetes & Obesity Program, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.ORCID 0000-0003-3790-6255
Monica NaguibCenter for Endocrinology, Diabetes and Metabolism, Diabetes & Obesity Program, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Jennifer K RaymondCenter for Endocrinology, Diabetes and Metabolism, Diabetes & Obesity Program, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Sarah Jeanne SalvyResearch Center for Health Equity, Cedars-Sinai Medical Center, Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA 90048, USA.ORCID 0000-0002-8202-182X
Elizabeth HegedusCenter for Endocrinology, Diabetes and Metabolism, Diabetes & Obesity Program, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Choo Phei WeeDepartment of Population and Public Health Sciences, Keck School of Medicine, Southern California Clinical and Translational Science Institute (SC-CTSI), Los Angeles, CA 90007, USA.
Michael I GoranCenter for Endocrinology, Diabetes and Metabolism, Diabetes & Obesity Program, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · UNIVERSITY OF SOUTHERN CALIFORNIA · 2025 to 2025
$9.1M
Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and ModeratorsR01CA258222 · CEDARS-SINAI MEDICAL CENTER · 2025 to 2025
$767k
National Center for Advancing Translational Science (NCATS) of the U.S. National Institutes of Health UL1TR001855National Institute on Minority Health and Health Disparities (NIMHD) Obesity Health Disparities Research Center U54MD000502NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855NCI NIH HHS R01 CA258222the Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD092483the National Cancer Institute 1R01CA258222
6 · The paper itself

Abstract

Due to its simplicity, time-limited eating (TLE) may represent a more feasible approach for treating adolescents with obesity compared to other caloric restriction regimens. This pilot study examines the feasibility and safety of TLE combined with continuous glucose monitoring (CGM) in adolescents. Fifty adolescents with BMI ≥95th percentile were recruited to complete a 12-week study. All received standard nutritional counseling, wore a CGM daily, and were randomized to: (1) Prolonged eating window: 12 h eating/12 h fasting + blinded CGM; (2) TLE (8 h eating/16 h fasting, 5 days per week) + blinded CGM; (3) TLE + real-time CGM feedback. Recruitment, retention, and adherence were recorded as indicators of feasibility. Weight loss, dietary intake, physical activity, eating behaviors, and quality of life over the course of the intervention were explored as secondary outcomes. Forty-five participants completed the study (16.4 ± 1.3 years, 64% female, 49% Hispanic, 75% public insurance). There was high adherence to prescribed eating windows (TLE 5.2 d/wk [SD 1.1]; control 6.1 d/wk [SD 1.4]) and daily CGM wear (5.85 d/wk [SD 4.8]). Most of the adolescents (90%) assigned to TLE reported that limiting their eating window and wearing a CGM was feasible without negative impact on daily functioning or adverse events. There were no between-group difference in terms of weight loss, energy intake, quality of life, physical activity, or eating behaviors. TLE combined with CGM appears feasible and safe among adolescents with obesity. Further investigation in larger samples, with a longer intervention duration and follow-up assessments are needed.

Indexed as

Blood Glucose Self-MonitoringFastingAdolescentAttitudeBehaviorEatingExerciseFeasibility StudiesFemaleHumansIntention to Treat AnalysisLinear ModelsMaleOutcome Assessment, Health CarePatient CompliancePediatric Obesityadolescentscontinuous glucose monitorintermittent fastingobesitypediatrics

Identifiers

PMID34835953
PMCPMC8624400

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.