Evidence map›Paper›PMID 34835984›Full record

SynthesisNutrients2021

Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials.

Laia Gutierrez, Alexandre Folch, Melina Rojas, José Luis Cantero, Mercedes Atienza, Jaume Folch, Antoni Camins, Agustín Ruiz, Christopher Papandreou, Mònica Bulló

Registry-linked trialOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06380998 (Effects of Petroleum Compounds on Psychological Health, Cognitive Functions, and the Possible Ameliorating Effect of Whey Protein in a Sample of Petrol Station Workers in Assiut Governorate), which is not on this map. Cited by 45 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06380998 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Effects of Petroleum Compounds on Psychological Health, Cognitive Functions, and the Possible Ameliorating Effect of Whey Protein in a Sample of Petrol Station Workers in Assiut Governorate

TypeobservationalSponsorAssiut UniversityRan2024 to 2027Enrolled196ConditionsCognitive DeteriorationArmswhey protien
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 94 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Laia GutierrezNutrition and Metabolic Disorders Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University, 43201 Reus, Spain.ORCID 0000-0003-4427-6845
Alexandre FolchNutrition and Metabolic Disorders Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University, 43201 Reus, Spain.
Melina RojasNutrition and Metabolic Disorders Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University, 43201 Reus, Spain.ORCID 0000-0002-4743-5613
José Luis CanteroLaboratory of Functional Neuroscience, Pablo de Olavide University, 41013 Seville, Spain.
Mercedes AtienzaLaboratory of Functional Neuroscience, Pablo de Olavide University, 41013 Seville, Spain.ORCID 0000-0002-6760-1252
Jaume FolchNutrition and Metabolic Disorders Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University, 43201 Reus, Spain.
Antoni CaminsCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, 28031 Madrid, Spain.ORCID 0000-0002-1229-5956
Agustín RuizCIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, 28031 Madrid, Spain.
Christopher PapandreouNutrition and Metabolic Disorders Research Group, Institute of Health Pere Virgili-IISPV, 43204 Reus, Spain.
Mònica BullóNutrition and Metabolic Disorders Research Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University, 43201 Reus, Spain.ORCID 0000-0002-0218-7046
Biomedical Research Networking Center on Neurodegenerative Diseases · ESInstitut de Recerca Biomèdica Catalunya Sud · ESInstituto de Salud Carlos III · ESUniversitat Internacional de Catalunya · ES

Funding

SYMPTOM AND EMOTION STIMULI TO HEALTH ACTION IN ELDERLYR01AG003501 · UNIVERSITY OF WISCONSIN MADISON · 1986 to 1989
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SYMPTOM &EMOTION STIMULI TO HEALTH ACTION IN THE ELDERLR37AG003501 · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · 1990 to 1999
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Government of Catalonia 2021 FI_B 00657Government of Catalonia SLT/3501/2020Instituto de Salud Carlos III CP 19/00189
6 · The paper itself

Abstract

New dietary approaches for the prevention of cognitive impairment are being investigated. However, evidence from dietary interventions is mainly from food and nutrient supplement interventions, with inconsistent results and high heterogeneity between trials. We conducted a comprehensive systematic search of randomized controlled trials (RCTs) published in MEDLINE-PubMed, from January 2018 to July 2021, investigating the impact of dietary counseling, as well as food-based and dietary supplement interventions on cognitive function in adults with or without cognitive impairment. Based on the search strategy, 197 eligible publications were used for data abstraction. Finally, 61 articles were included in the analysis. There was reasonable evidence that dietary patterns, as well as food and dietary supplements improved cognitive domains or measures of brain integrity. The Mediterranean diet showed promising results, whereas the role of the DASH diet was not clear. Healthy food consumption improved cognitive function, although the quality of these studies was relatively low. The role of dietary supplements was mixed, with strong evidence of the benefits of polyphenols and combinations of nutrients, but with low evidence for PUFAs, vitamin D, specific protein, amino acids, and other types of supplements. Further well-designed RCTs are needed to guide the development of dietary approaches for the prevention of cognitive impairment.

Indexed as

NutrientsRandomized Controlled Trials as TopicAdultCognitionCognitive DysfunctionCounselingDietDietary SupplementsFatty Acids, UnsaturatedHumansPolyphenolsPublication BiasRiskSample SizeVitaminsFatty Acids, UnsaturatedNutrientsPolyphenolsVitaminsAlzheimer’s diseasecognitive impairmentdietdietary interventionsfoodhealthysubjective cognitive declinesupplements

Identifiers

PMID34835984
PMCPMC8621754
OpenAlexW3208717213

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.