Evidence map›Paper›PMID 34838449›Full record

ArticleJournal of diabetes and its complications2022

Neural correlates of slower gait in middle-aged persons with childhood-onset type 1 diabetes mellitus: The impact of accelerated brain aging.

Sarah K Royse, Tina Costacou, Karen A Nunley, Trevor J Orchard, Caterina Rosano

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes and its complications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sarah K RoyseDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: sak225@pitt.edu.
Tina CostacouDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: costacout@edc.pitt.edu.
Karen A NunleyChronic Disease Epidemiology Branch, Community Health Improvement Division, Texas Department of State Health Services, Austin, TX, USA.
Trevor J OrchardDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: orcardt@edc.pitt.edu.
Caterina RosanoDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: rosanoc@edc.pitt.edu.
University of Pittsburgh · USTexas Department of State Health Services · US

Funding

Epidemiology of Diabetes Complications (EDC) Phase II: renewalR37DK034818 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ORCHARD, TREVOR J. · 2009 to 2018
$6.5M
EPIDEMIOLOGY OF DIABETIC COMPLICATIONS--PHASE IIR01DK034818 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COSTACOU, TINA · 1986 to 2019
$5.6M
Imaging biomarkers of accelerated brain aging in Type-1 DiabetesR01DK089028 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSANO, CATERINA · 2010 to 2013
$2.3M
NIDDK NIH HHS R01 DK034818NIDDK NIH HHS R01 DK089028NIDDK NIH HHS R37 DK034818
6 · The paper itself

Abstract

aimsWe aimed to determine if neuroimaging characteristics of gray and white matter are associated with gait speed in middle-aged individuals with childhood-onset type 1 diabetes (T1D), and whether associations are independent of diabetic peripheral neuropathy (DPN) status.

methodsIn a cohort of 100 middle-aged adults with childhood-onset T1D (aged 49.2 ± 7.0 years, 50F/50M), we assessed cross-sectional associations of DPN, severity of white matter hyperintensities (WMH; Fazekas score), and regional gray matter volume (GMV) with gait speed. Associations were tested separately and combined in linear regression models adjusted for diabetes duration and locomotor risk factors.

resultsAverage gait speed was 1.3 m/s, with 52% of participants walking below the age-appropriate range of 1.3-1.5 m/s. In separate models, higher WMH severity (β = -0.27, p = 0.01) and smaller caudate GMV (β = -0.21, p = 0.04), but not DPN (β = -0.20, p = 0.08) were associated with slower gait speed. When combined, only WMH severity remained significant (β = -0.22, p = 0.04).

conclusionsMore than half of participants walked more slowly than expected based on age. Gait speed was slower among those with more severe WMH independent of locomotor risk factors. Gait slowing in middle-aged persons with T1D may reflect brain changes, and thus, deserve further attention.

Indexed as

Diabetes Mellitus, Type 1AdultAgingBrainChildCross-Sectional StudiesGaitHumansMagnetic Resonance ImagingMiddle AgedDiabetic peripheral neuropathyGait speedGray matter volumeType 1 diabetesWhite matter hyperintensities

Identifiers

PMID34838449
PMCPMC8818038
OpenAlexW3213927471

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.