Evidence map›Paper›PMID 34845021›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

In vivo visualization of butterfly scale cell morphogenesis in

Anthony D McDougal, Sungsam Kang, Zahid Yaqoob, Peter T C So, Mathias Kolle

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Damselflies overcome color saturation barriers of photonic glasses via pigment loading and refractive index modulation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Hierarchical woven fibrillar structures in developing single gyroids in butterflies.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  12. In vivo visualization of butterfly scale cell morphogenesis inProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anthony D McDougalDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-9980-4193
Sungsam KangLaser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139.
Zahid YaqoobLaser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0003-2487-9497
Peter T C SoDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0003-4698-6488
Mathias KolleDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; mkolle@mit.edu.ORCID 0000-0001-7395-8824
Massachusetts Institute of Technology · US

Funding

Wide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3M
Research Supplement - Quantitative analyses of tumor cell extravasationU01CA202177 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KAMM, ROGER D · 2015 to 2020
$4.2M
High-Performance Imaging Through Scattering Living TissueR01DA045549 · NIDA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOYDEN, EDWARD S. · 2017 to 2020
$3.5M
Single-cell measurement of cyclic stress on sickle blood cells by imaging-microfluidicsR01HL158102 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DAO, MING, HIGGINS, JOHN MATTHEW · 2021 to 2024
$2.4M
Acoustically-driven optical-interferometric microscope for cell characterizationR21GM140613 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANTHONY, BRIAN W, SO, PETER T. · 2021 to 2022
$424k
NCI NIH HHS U01 CA202177NHLBI NIH HHS R01 HL158102NIBIB NIH HHS P41 EB015871NIDA NIH HHS R01 DA045549NIGMS NIH HHS R21 GM140613
6 · The paper itself

Abstract

During metamorphosis, the wings of a butterfly sprout hundreds of thousands of scales with intricate microstructures and nano-structures that determine the wings' optical appearance, wetting characteristics, thermodynamic properties, and aerodynamic behavior. Although the functional characteristics of scales are well known and prove desirable in various applications, the dynamic processes and temporal coordination required to sculpt the scales' many structural features remain poorly understood. Current knowledge of scale growth is primarily gained from ex vivo studies of fixed scale cells at discrete time points; to fully understand scale formation, it is critical to characterize the time-dependent morphological changes throughout their development. Here, we report the continuous, in vivo, label-free imaging of growing scale cells of

Indexed as

AnimalsAnimal ScalesButterfliesColorLepidopteraMetamorphosis, BiologicalMorphogenesisPigmentationWings, Animalbiological structure formationbutterfly scalescuticle secretionin vivo quantitative phase imagingmetamorphosis

Identifiers

PMID34845021
PMCPMC8670486
OpenAlexW3215687989

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.