ReviewThe Journal of allergy and clinical immunology2022
The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions.
Erratum issuedOpen access · bronzeAbstract readReview
In one paragraph
Review in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Individualized interventions and precision health: Lessons learned from a systematic review and implications for analytics-driven geriatric research.Journal of the American Geriatrics Society · 2023Pooled it
- PrecISE-a biomarker-stratified adaptive trial of 5 interventions in severe asthma: Final protocol and the baseline cohort.The Journal of allergy and clinical immunology · 2026Trial
- Precision medicine in asthma: endotype stratification, biomarker-guided biologics, and emerging therapeutic strategies.Molecular biology reports · 2026Review
- β-Hydroxybutyrate attenuates bronchial smooth muscle proinflammatory cytokine production and contraction.American journal of physiology. Cell physiology · 2026Article
- Toward precision for bronchopulmonary dysplasia: Moving past current definitions.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Harmonized low-dose computed tomographic protocols for quantitative lung imaging using dose modulation and advanced reconstructions.Medical physics · 2025Article
- Impact of clinical factors and season on inflammatory cytokines in biologic-treated and untreated asthma.Respiratory research · 2025Article
- CompEx Asthma: is it time for a change in clinical trials?The European respiratory journal · 2025Article
- Unraveling the mechanisms of virus-induced asthma exacerbation: epithelial injury, immune dysregulation, and novel interventions.Chinese medical journal pulmonary and critical care medicine · 2025Review
- The Impact of the Indoor Environment on Childhood Asthma.Current allergy and asthma reports · 2025Review
- Designing for trustworthiness and research reciprocity: An example from the Illinois research network hub in the NIH RECOVER adult cohort study.Journal of clinical and translational science · 2025Article
- Non-Pharmaceutical Interventions May Attenuate Acute Exacerbations of Asthma: Experience During the COVID-19 Pandemic in Taiwan.Journal of asthma and allergy · 2025Article
- Obesity-related Asthma: A Pathobiology-based Overview of Existing and Emerging Treatment Approaches.American journal of respiratory and critical care medicine · 2024Review
- Automated Cough Analysis with Convolutional Recurrent Neural Network.Bioengineering (Basel, Switzerland) · 2024Article
- Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- Ciliary Function, Antigen Stasis and Asthma.International journal of molecular sciences · 2024Review
- Novel Machine Learning Identifies 5 Asthma Phenotypes Using Cluster Analysis of Real-World Data.The journal of allergy and clinical immunology. In practice · 2024Article
- Emerging cell and molecular targets for treating mucus hypersecretion in asthma.Allergology international : official journal of the Japanese Society of Allergology · 2024Review
- Reply to MozaffaripourAmerican journal of respiratory and critical care medicine · 2024Article
- Review
Corrections and comments
- Erratum issuedCorrigendum.2022
Authors and funding
61 authors at 20 institutions in 2 countries.
Steve N GeorasDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Rochester Medical Center, Rochester, NY. Electronic address: Steve_Georas@urmc.rochester.edu.
Rosalind J WrightIcahn School of Medicine at Mount Sinai, New York, NY.
Anastasia IvanovaDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Elliot IsraelDepartment of Medicine, Divisions of Pulmonary & Critical Care Medicine & Allergy & Immunology, Brigham & Women's Hospital, Harvard Medical School, Boston, Mass.
Lisa M LaVangeDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Praveen AkuthotaPulmonary Division, Department of Medicine, University of California-San Diego, La Jolla, Calif.
Tara F CarrAsthma and Airway Disease Research Center, University of Arizona, Tucson, Ariz.
Loren C DenlingerDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
Merritt L FajtUniversity of Pittsburgh Asthma Institute, University of Pittsburgh, Pittsburgh, Pa.
Rajesh KumarLurie Children's Hospital, Chicago, Ill.
Wanda K O'NealCenter for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, NC.
Wanda PhipatanakulBoston Children's Hospital and Harvard Medical School, Boston, Mass.
Stanley J SzeflerChildren's Hospital Colorado, Aurora, Colo; University of Colorado School of Medicine, Aurora, Colo.
Mark A AronicaLerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Leonard B BacharierVanderbilt University School of Medicine, Nashville, Tenn.
Allison J BurbankCenter for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, NC.
Mario CastroUniversity of Kansas School of Medicine, Kansas City, Mo.
Laura Crotty AlexanderPulmonary Division, Department of Medicine, University of California-San Diego, La Jolla, Calif.
Julie BamdadDivision of Lung Diseases, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Md.
Juan Carlos CardetAllergy and Immunology, University of South Florida, Tampa, Fla.
Suzy A A ComhairLerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Ronina A CovarNational Jewish Health, Denver, Colo.
Emily A DiMangoColumbia University Medical Center, New York, NY.
Kim ErwinInstitute for Healthcare Delivery Design, University of Illinois at Chicago, Chicago, Ill.
Serpil C ErzurumLerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
John V FahyUniversity of California, San Francisco School of Medicine, San Francisco, Calif.
Jonathan M GaffinBoston Children's Hospital and Harvard Medical School, Boston, Mass.
Benjamin GastonWells Center for Pediatric Research, Indiana University, Indianapolis, Ind.
Lynn B GeraldAsthma and Airway Disease Research Center, University of Arizona, Tucson, Ariz.
Eric A HoffmanDepartment of Radiology, University of Iowa, Iowa City, Iowa.
Fernando HolguinUniversity of Colorado School of Medicine, Aurora, Colo.
Daniel J JacksonDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
John JamesDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Nizar N JarjourDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
Nicholas J KenyonDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California Davis School of Medicine, Davis, Calif.
Sumita KhatriRespiratory Institute, Cleveland Clinic, Cleveland, Ohio.
John P KirwanPennington Biomedical Research Center, Louisiana State University, Baton Rouge, La.
Monica KraftAsthma and Airway Disease Research Center, University of Arizona, Tucson, Ariz.
Jerry A KrishnanDivision of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, Ill.
Andrew H LiuChildren's Hospital Colorado, Aurora, Colo; University of Colorado School of Medicine, Aurora, Colo.
Mark C LiuPulmonary and Critical Care Medicine, Department of Medicine, the Johns Hopkins University, Baltimore, Md.
M Alison MarquisDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Fernando MartinezAsthma and Airway Disease Research Center, University of Arizona, Tucson, Ariz.
Jacob MeyPennington Biomedical Research Center, Louisiana State University, Baton Rouge, La.
Wendy C MooreWake Forest University School of Medicine, Winston-Salem, NC.
James N MoyRush University Medical Center, Chicago, Ill.
Victor E OrtegaWake Forest University School of Medicine, Winston-Salem, NC.
David B PedenCenter for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, NC.
Emily PenningtonThe Cleveland Clinic, Cleveland, Ohio.
Michael C PetersUniversity of California, San Francisco School of Medicine, San Francisco, Calif.
Kristie RossThe Cleveland Clinic, Cleveland, Ohio; UH Rainbow Babies and Children's Hospitals, Cleveland, Ohio.
Maria SanchezDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Lewis J SmithNorthwestern University, Chicago, Ill.
Ronald L SorknessDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
Michael E WechslerChildren's Hospital Colorado, Aurora, Colo; University of Colorado School of Medicine, Aurora, Colo.
Sally E WenzelUniversity of Pittsburgh Asthma Institute, University of Pittsburgh, Pittsburgh, Pa.
Steven R WhiteSection of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Ill.
Joe ZeinRespiratory Institute, Cleveland Clinic, Cleveland, Ohio.
Amir A ZekiDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California Davis School of Medicine, Davis, Calif.
Patricia NoelDivision of Lung Diseases, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Md.
PrecISE Study Team
University of North Carolina at Chapel Hill · USChildren's Hospital Colorado · USUniversity of Wisconsin–Madison · USCleveland Clinic · USJohns Hopkins University · USUniversity of Rochester Medical Center · USRush University Medical Center · USNational Institutes of Health · USUniversity of Arizona · USBoston Children's Hospital · USCleveland Clinic Lerner College of Medicine · USPennington Biomedical Research Center · USUniversity of California San Diego · USUniversity of Chicago · USColumbia University Irving Medical Center · USIcahn School of Medicine at Mount Sinai · USUniversity of California, Davis · USUniversity of California, San Francisco · USUniversity of Illinois Chicago · USUniversity of Kansas · US
Funding
SPORE IN BREAST CANCERP50CA058223 · UNIV OF NORTH CAROLINA CHAPEL HILL · 1992 to 2025
$18.8MVISUAL INDICES OF NEUROTOXICITYP30ES001247 · UNIVERSITY OF ROCHESTER · 1985 to 2025
$10.5MUniversity of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$10.1MUniversity of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · UNIVERSITY OF WISCONSIN-MADISON · 2025 to 2025
$8.9MPulmonary Toxicology FacilityP30ES005605 · UNIVERSITY OF IOWA · 1990 to 2025
$8.8MClinical and Translational Science InstituteUL1TR001872 · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2025 to 2025
$8.5MThe Institute for Translational MedicineUL1TR002389 · UNIVERSITY OF CHICAGO · 2025 to 2025
$7.6MLouisiana Clinical and Translational Science CenterU54GM104940 · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · 2025 to 2025
$3.9MFrontiers Clinical and Translational Science Institute at the University of KansasUL1TR002366 · UNIVERSITY OF KANSAS MEDICAL CENTER · 2025 to 2025
$3.7MMOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · 1996 to 2025
$3.1MUC Davis Environmental Health Sciences Core CenterP30ES023513 · UNIVERSITY OF CALIFORNIA AT DAVIS · 2025 to 2025
$1.6MUpper Airway Microbial Development During the First Year of LifeK23AI135094 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI Kirsten M Kloepfer · 2022 to 2022
$183kNCATS NIH HHS U24 TR001608NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR001422NCATS NIH HHS UL1 TR001442NCATS NIH HHS UL1 TR001857NCATS NIH HHS UL1 TR001872NCATS NIH HHS UL1 TR002366NCATS NIH HHS UL1 TR002373NCATS NIH HHS UL1 TR002389NCATS NIH HHS UL1 TR002489NCI NIH HHS P50 CA058223NHLBI NIH HHS L30 HL149106NHLBI NIH HHS R01 HL148715NHLBI NIH HHS R03 HL148486NHLBI NIH HHS U24 HL138998NHLBI NIH HHS UG1 HL139054NHLBI NIH HHS UG1 HL139098NHLBI NIH HHS UG1 HL139106NHLBI NIH HHS UG1 HL139117NHLBI NIH HHS UG1 HL139118NHLBI NIH HHS UG1 HL139119NHLBI NIH HHS UG1 HL139123NHLBI NIH HHS UG1 HL139124NHLBI NIH HHS UG1 HL139125NHLBI NIH HHS UG1 HL139126NIAID NIH HHS K23 AI125785NIAID NIH HHS K23 AI135094NIAID NIH HHS R03 AI139648NIAID NIH HHS T32 AI007512NIAID NIH HHS U01 AI097073NIEHS NIH HHS P30 ES001247NIEHS NIH HHS P30 ES005605NIEHS NIH HHS P30 ES023513NIGMS NIH HHS U54 GM104940
Abstract
Asthma is a heterogeneous disease, with multiple underlying inflammatory pathways and structural airway abnormalities that impact disease persistence and severity. Recent progress has been made in developing targeted asthma therapeutics, especially for subjects with eosinophilic asthma. However, there is an unmet need for new approaches to treat patients with severe and exacerbation-prone asthma, who contribute disproportionately to disease burden. Extensive deep phenotyping has revealed the heterogeneous nature of severe asthma and identified distinct disease subtypes. A current challenge in the field is to translate new and emerging knowledge about different pathobiologic mechanisms in asthma into patient-specific therapies, with the ultimate goal of modifying the natural history of disease. Here, we describe the Precision Interventions for Severe and/or Exacerbation-Prone Asthma (PrecISE) Network, a groundbreaking collaborative effort of asthma researchers and biostatisticians from around the United States. The PrecISE Network was designed to conduct phase II/proof-of-concept clinical trials of precision interventions in the population with severe asthma, and is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health. Using an innovative adaptive platform trial design, the PrecISE Network will evaluate up to 6 interventions simultaneously in biomarker-defined subgroups of subjects. We review the development and organizational structure of the PrecISE Network, and choice of interventions being studied. We hope that the PrecISE Network will enhance our understanding of asthma subtypes and accelerate the development of therapeutics for severe asthma.
Indexed as
Precision MedicineAdaptive Clinical Trials as TopicAdvisory CommitteesAsthmaBiomarkersClinical ProtocolsClinical Trials, Phase II as TopicHumansResearch DesignSeverity of Illness IndexTomography, X-Ray ComputedBiomarkersadaptive clinical trial designasthma exacerbationbiomarkernon–type 2 asthmapatient advisory committeeprecision medicineSevere asthmatype 2 asthma
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.