ArticleNature communications2021
Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Shape-independent fluidity in epithelial cell monolayers.Nature communications · 2026Article
- Cell divisions both challenge and refine tissue boundaries in the Drosophila embryo.Development (Cambridge, England) · 2026Article
- Cell jamming transition is regulated by mitochondrial pyruvate transport and endocytosis.bioRxiv : the preprint server for biology · 2026Article
- Linking Planar Cell Polarity to Mechanotransduction During Morphogenesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Tissue fluidity mediates a trade-off between the speed and accuracy of multicellular patterning by cell sorting.Biophysical journal · 2025Article
- An integrated platform for liquid handling and cell imaging in life science applications.Nature communications · 2025Article
- Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025Article
- Tissue Fluidity Mediates a Trade-off Between the Speed and Accuracy of Multicellular Patterning by Cell Sorting.bioRxiv : the preprint server for biology · 2025Article
- Prickle2 regulates apical junction remodeling and tissue fluidity during vertebrate neurulation.The Journal of cell biology · 2025Article
- Radial rotation of cell-pair under beam mode coupling effect of microcavity cascaded single fiber optical tweezers.Nanophotonics (Berlin, Germany) · 2025Article
- Signatures of structural disorder in the developingPRX life · 2024Article
- E-cadherin tunes tissue mechanical behavior before and during morphogenetic tissue flows.Current biology : CB · 2024Article
- Mechanical state transitions in the regulation of tissue form and function.Nature reviews. Molecular cell biology · 2024Review
- An emerging role for tissue plasticity in developmental precision.Biochemical Society transactions · 2024Review
- Adherens junctions as molecular regulators of emergent tissue mechanics.Nature reviews. Molecular cell biology · 2024Review
- Core PCP mutations affect short-time mechanical properties but not tissue morphogenesis in theeLife · 2023Article
- FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor.Development (Cambridge, England) · 2023Article
- Quantitative videomicroscopy reveals latent control of cell-pair rotations in vivo.Development (Cambridge, England) · 2023Article
- A cell membrane model that reproduces cortical flow-driven cell migration and collective movement.Frontiers in cell and developmental biology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The phenomenon of tissue fluidity-cells' ability to rearrange relative to each other in confluent tissues-has been linked to several morphogenetic processes and diseases, yet few molecular regulators of tissue fluidity are known. Ommatidial rotation (OR), directed by planar cell polarity signaling, occurs during Drosophila eye morphogenesis and shares many features with polarized cellular migration in vertebrates. We utilize in vivo live imaging analysis tools to quantify dynamic cellular morphologies during OR, revealing that OR is driven autonomously by ommatidial cell clusters rotating in successive pulses within a permissive substrate. Through analysis of a rotation-specific nemo mutant, we demonstrate that precise regulation of junctional E-cadherin levels is critical for modulating the mechanical properties of the tissue to allow rotation to progress. Our study defines Nemo as a molecular tool to induce a transition from solid-like tissues to more viscoelastic tissues broadening our molecular understanding of tissue fluidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.