Evidence map›Paper›PMID 34849152›Full record

ArticleExperimental and therapeutic medicine2022

Acute kidney injury in moderate and severe COVID-19 patients: Report of two university hospitals.

Daniela Radulescu, Liliana-Ana Tuta, Cristiana David, Carmen Bogeanu, Simona Daniela Onofrei, Elena Stepan, Elena Cuiban, Andreea Ciofalca, Larisa Florina Feier, Camelia Pana and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Daniela RadulescuClinical Department No. 3, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Liliana-Ana TutaFaculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.
Cristiana DavidClinical Department No. 3, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Carmen BogeanuClinical Department No. 3, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Simona Daniela OnofreiClinical Department No. 3, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Elena StepanDepartment of Nephrology and Dialysis, 'Sf. Ioan' Emergency Clinical Hospital, 421422 Bucharest, Romania.
Elena CuibanDepartment of Nephrology and Dialysis, 'Sf. Ioan' Emergency Clinical Hospital, 421422 Bucharest, Romania.
Andreea CiofalcaDepartment of Nephrology and Dialysis, 'Sf. Ioan' Emergency Clinical Hospital, 421422 Bucharest, Romania.
Larisa Florina FeierDepartment of Nephrology and Dialysis, 'Sf. Ioan' Emergency Clinical Hospital, 421422 Bucharest, Romania.
Camelia PanaFaculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.
Magda-Cristina NutuFaculty of Medicine, 'Ovidius' University, 900470 Constanta, Romania.
Ileana Adela VacaroiuClinical Department No. 3, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Carol Davila University of Medicine and Pharmacy · ROClinical Emergency Hospital Bucharest · ROOvidius University · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is one of the most severe complications of SARS-CoV-2 infection. In a retrospective study, we aimed to describe the influence of COVID-19-related factors on the severity, outcome and timing of AKI in 268 patients admitted in two large COVID-19-designated university hospitals over a period of 6 months. In the univariate analysis, there was a significant relationship between KDIGO stage and the extension of COVID-19 pneumonia on computed tomography (CT), need for oxygen supplementation, serum levels of ferritin, interleukin-6, and procalcitonin, but none of these variables had a value for predicting KDIGO stage in multinomial regression. The odds of recovery of renal function were significantly diminished by d-dimer values. Lack of immunomodulatory treatment was found to be correlated with increased need for renal replacement therapy (RRT). Compared with AKI at admission, hospital-acquired AKI was predicted by the severity of lung damage on CT, evolved more frequently with incomplete recovery of renal function, and was significantly associated with antiviral therapy.

Indexed as

acute kidney injurymarkers of inflammationpercentages of affected pulmonary parenchymarenal outcomeSARS-CoV-2 infectiontiming of acute kidney injury

Identifiers

PMID34849152
PMCPMC8613528
OpenAlexW3214234460

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.