Evidence map›Paper›PMID 34849191›Full record

ArticleComputational and structural biotechnology journal2021

Novel dynamic residue network analysis approaches to study allosteric modulation: SARS-CoV-2 M

Olivier Sheik Amamuddy, Rita Afriyie Boateng, Victor Barozi, Dorothy Wavinya Nyamai, Özlem Tastan Bishop

Open access · goldAbstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  6. Revealing SARS-CoV-2 MComputational and structural biotechnology journal · 2024
    Article
  7. Review
  8. Review
  9. Global Analysis ofMolecules (Basel, Switzerland) · 2022
    Article
  10. Viral proteases as therapeutic targets.Molecular aspects of medicine · 2022
    Review
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  12. Article
  13. Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Olivier Sheik AmamuddyResearch Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda, South Africa.
Rita Afriyie BoatengResearch Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda, South Africa.
Victor BaroziResearch Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda, South Africa.
Dorothy Wavinya NyamaiResearch Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda, South Africa.
Özlem Tastan BishopResearch Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda, South Africa.
Rhodes University · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rational search for allosteric modulators and the allosteric mechanisms of these modulators in the presence of mutations is a relatively unexplored field. Here, we established novel

Indexed as

Allosteric modulatorsBetweenness centralityCloseness centralityDegree centralityDynamic residue network analysisEigencentralityEvolutionary mutationsHomodimeric proteinKatz centralityMDM-TASK-webMD-TASKNatural compounds

Identifiers

PMID34849191
PMCPMC8613987
OpenAlexW3214909952

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.