ArticleG3 (Bethesda, Md.)2021
Widespread retention of ohnologs in key developmental gene families following whole-genome duplication in arachnopulmonates.
Article in G3 (Bethesda, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Pax6 homologs are required for patterning both visual systems of the daddy-longlegs Phalangium opilio.Molecular biology and evolution · 2026Article
- An ancient genome duplication event drives the development and evolution of spinnerets in spiders.Science advances · 2026Article
- Molecular Mechanisms of Venom Diversity.Toxins · 2025Review
- Gene and Genome Duplication in Spiders.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Review
- Article
- Three Novel Spider Genomes Unveil Spidroin Diversification and Hox Cluster Architecture: Ryuthela nishihirai (Liphistiidae), Uloborus plumipes (Uloboridae) and Cheiracanthium punctorium (Cheiracanthiidae).Molecular ecology resources · 2025Article
- Single-cell sequencing suggests a conserved function of Hedgehog-signalling in spider eye development.EvoDevo · 2024Article
- Gene Function is a Driver of Activin Signaling Pathway Evolution Following Whole-Genome Duplication in Rainbow Trout (Oncorhynchus mykiss).Genome biology and evolution · 2024Article
- Evolution of the Spider Homeobox Gene Repertoire by Tandem and Whole Genome Duplication.Molecular biology and evolution · 2023Article
- Expression of posterior Hox genes and opisthosomal appendage development in a mygalomorph spider.Development genes and evolution · 2023Article
- A homology guide for Pacific salmon genusEcology and evolution · 2023Article
- Dual Functions of labial Resolve the Hox Logic of Chelicerate Head Segments.Molecular biology and evolution · 2023Article
- Comprehensive Species Sampling and Sophisticated Algorithmic Approaches Refute the Monophyly of Arachnida.Molecular biology and evolution · 2022Article
- Phylogenetic analysis of forkhead transcription factors in the Panarthropoda.Development genes and evolution · 2022Article
- Lack of evidence for conserved parasegmental grooves in arthropods.Development genes and evolution · 2022Article
- The organizing role of Wnt signaling pathway during arthropod posterior growth.Frontiers in cell and developmental biology · 2022Review
- The Tetragnatha kauaiensis Genome Sheds Light on the Origins of Genomic Novelty in Spiders.Genome biology and evolution · 2021Article
- A chelicerate Wnt gene expression atlas: novel insights into the complexity of arthropod Wnt-patterning.EvoDevo · 2021Article
- The Evolution of Sox Gene Repertoires and Regulation of Segmentation in Arachnids.Molecular biology and evolution · 2021Article
- Systemic paralogy and function of retinal determination network homologs in arachnids.BMC genomics · 2020Article
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
Abstract
Whole-genome duplications (WGDs) have occurred multiple times during animal evolution, including in lineages leading to vertebrates, teleosts, horseshoe crabs, and arachnopulmonates. These dramatic events initially produce a wealth of new genetic material, generally followed by extensive gene loss. It appears, however, that developmental genes such as homeobox genes, signaling pathway components and microRNAs are frequently retained as duplicates (so-called ohnologs) following WGD. These not only provide the best evidence for WGD, but an opportunity to study its evolutionary consequences. Although these genes are well studied in the context of vertebrate WGD, similar comparisons across the extant arachnopulmonate orders are patchy. We sequenced embryonic transcriptomes from two spider species and two amblypygid species and surveyed three important gene families, Hox, Wnt, and frizzled, across these and 12 existing transcriptomic and genomic resources for chelicerates. We report extensive retention of putative ohnologs, further supporting the ancestral arachnopulmonate WGD. We also found evidence of consistent evolutionary trajectories in Hox and Wnt gene repertoires across three of the six arachnopulmonate orders, with interorder variation in the retention of specific paralogs. We identified variation between major clades in spiders and are better able to reconstruct the chronology of gene duplications and losses in spiders, amblypygids, and scorpions. These insights shed light on the evolution of the developmental toolkit in arachnopulmonates, highlight the importance of the comparative approach within lineages, and provide substantial new transcriptomic data for future study.
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