Evidence map›Paper›PMID 34851798›Full record

ArticleAmerican journal of respiratory cell and molecular biology2022

Human Rhinovirus Infection of the Respiratory Tract Affects Sphingolipid Synthesis.

Emily Wasserman, Rika Gomi, Anurag Sharma, Seunghee Hong, Rohan Bareja, Jinghua Gu, Uthra Balaji, Arul Veerappan, Benjamin I Kim, Wenzhu Wu and 6 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Emily WassermanDepartment of Pediatrics.ORCID 0000-0003-3700-8375
Rika GomiDepartment of Pediatrics.
Anurag SharmaDepartment of Pediatrics.
Seunghee HongDrukier Institute for Children's Health.
Rohan BarejaEnglaender Institute for Precision Medicine.
Jinghua GuDrukier Institute for Children's Health.
Uthra BalajiDrukier Institute for Children's Health.
Arul VeerappanDepartment of Physiology, and.
Benjamin I KimDepartment of Pathology and Cell Biology, and.
Wenzhu WuDepartment of Pediatrics.
Andrea HerasDepartment of Pediatrics.
Jose Perez-ZoghbiDepartment of Anesthesiology, Columbia University, New York, New York.
Biin SungDepartment of Pediatrics.
Seyni Gueye-NdiayeDepartment of Pediatrics.
Tilla S WorgallDepartment of Pathology and Cell Biology, and.
Stefan WorgallDepartment of Pediatrics.
Children’s Health Research Institute · CAColumbia University · USCornell University · USCzech Academy of Sciences, Institute of Physiology · CZPrecision for Medicine (United States) · US

Funding

Institutional Career Development CoreKL2TR002385 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI YUAN-SHAN ZHU · 2017 to 2026
$13.3M
Rhinovirus respiratory infection and sphingolipid metabolismR21AI140724 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI WORGALL, STEFAN · 2018 to 2019
$479k
NCATS NIH HHS KL2 TR002385NIAID NIH HHS R21 AI140724
6 · The paper itself

Abstract

The 17q21 asthma susceptibility locus includes asthma risk alleles associated with decreased sphingolipid synthesis, likely resulting from increased expression of ORMDL3. ORMDL3 inhibits serine-palmitoyl transferase (SPT), the rate-limiting enzyme of

Indexed as

Membrane ProteinsRhinovirusAnimalsChildHumansLungMiceSerine C-PalmitoyltransferaseSphingolipidsMembrane ProteinsORMDL3 protein, mouseSerine C-PalmitoyltransferaseSphingolipids17q21asthmaearly childhood wheezerhinovirussphingolipids

Identifiers

PMID34851798
PMCPMC8937237
OpenAlexW3216202204

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.