Evidence map›Paper›PMID 34853152›Full record

ArticleMolecular pharmacology2022

Phenylalanine 193 in Extracellular Loop 2 of the

Michael Ippolito, Francesco De Pascali, Asuka Inoue, Jeffrey L Benovic

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Advances in the Association Between theCurrent issues in molecular biology · 2026
    Review
  3. Synthesis and Characterization of Photoswitchable Covalent Ligands for the βAngewandte Chemie (International ed. in English) · 2025
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Michael IppolitoDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, (M.I., F.D.P., J.L.B.); and Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan (A.I.).
Francesco De PascaliDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, (M.I., F.D.P., J.L.B.); and Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan (A.I.).
Asuka InoueDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, (M.I., F.D.P., J.L.B.); and Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan (A.I.).
Jeffrey L BenovicDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, (M.I., F.D.P., J.L.B.); and Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan (A.I.) jeffrey.benovic@jefferson.edu.
Thomas Jefferson University · USTohoku University · JP

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Claudio Guillermo Giraudo · 1995 to 2026
$94.8M
Project 4 - OGR1- and TSPO- dependent mechanisms mediated by benzodiazepines affecting ASM contractionP01HL114471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BENOVIC, JEFFREY L · 2013 to 2023
$23.9M
Regulation of G protein-coupled receptor signaling and traffickingR35GM122541 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 2017 to 2021
$2.5M
Characterization of beta-arrestin-biased beta 2-adrenergic receptor signaling in cardiovascular functionR01HL136219 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L, TILLEY, DOUGLAS · 2017 to 2020
$2.5M
Training Program in Cellular, Biochemical, and Molecular SciencesT32GM100836 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI BENOVIC, JEFFREY L · 2012 to 2016
$809k
Characterization and Development of Gs-biased ligands of Beta2-Adrenergic ReceptorF31HL139104 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI IPPOLITO, MICHAEL · 2018 to 2019
$90k
NCI NIH HHS P30 CA056036NHLBI NIH HHS F31 HL139104NHLBI NIH HHS P01 HL114471NHLBI NIH HHS R01 HL136219NIGMS NIH HHS R35 GM122541NIGMS NIH HHS T32 GM100836
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) transduce a diverse variety of extracellular stimuli into intracellular signaling. These receptors are the most clinically productive drug targets at present. Despite decades of research on the signaling consequences of molecule-receptor interactions, conformational components of receptor-effector interactions remain incompletely described. The

Indexed as

Amino Acid Sequencebeta-ArrestinsDose-Response Relationship, DrugExtracellular FluidGene Knockout TechniquesHEK293 CellsHumansPhenylalanineProtein Structure, SecondaryReceptors, Adrenergic, beta-2ADRB2 protein, humanbeta-ArrestinsPhenylalanineReceptors, Adrenergic, beta-2

Identifiers

PMID34853152
PMCPMC8969133
OpenAlexW3215503891

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.