Evidence map›Paper›PMID 34854257›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Periosteal CD68

Ruoxian Deng, Changwei Li, Xiao Wang, Leilei Chang, Shuangfei Ni, Weixin Zhang, Peng Xue, Dayu Pan, Mei Wan, Lianfu Deng and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Ruoxian DengDepartment of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.ORCID 0000-0002-5540-6767
Changwei LiShanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Xiao WangDepartment of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Leilei ChangShanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Shuangfei NiDepartment of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Weixin ZhangDepartment of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Peng XueDepartment of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Dayu PanDepartment of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Mei WanDepartment of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Lianfu DengShanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Xu CaoDepartment of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Johns Hopkins University · USRuijin Hospital · CN

Funding

Skeleton and Joint Degeneration with AgingP01AG066603 · NIA · JOHNS HOPKINS UNIVERSITY · PI CAO, XU · 2021 to 2025
$9.2M
Trap+ Mononuclear Cells in Periosteal Bone FormationR01AR071432 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CAO, XU · 2017 to 2021
$2.2M
Subchondral Bone Cavities in Osteoarthritis PainR01AG068997 · NIA · JOHNS HOPKINS UNIVERSITY · PI CAO, XU, GUAN, YUN · 2024 to 2024
$621k
National Institute on Aging of the National Institutes of Health P01AG066603NIAMS NIH HHS R01 AR071432NIA NIH HHS P01 AG066603NIA NIH HHS R01 AG068997NIH HHS AR071432
6 · The paper itself

Abstract

Mechanical force regulates bone density, modeling, and homeostasis. Substantial periosteal bone formation is generated by external mechanical stimuli, yet its mechanism is poorly understood. Here, it is shown that myeloid-lineage cells differentiate into subgroups and regulate periosteal bone formation in response to mechanical loading. Mechanical loading on tibiae significantly increases the number of periosteal myeloid-lineage cells and the levels of active transforming growth factor β (TGF-β), resulting in cortical bone formation. Knockout of Tgfb1 in myeloid-lineage cells attenuates mechanical loading-induced periosteal bone formation in mice. Moreover, CD68

Indexed as

AnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticB7-1 AntigenCD68 MoleculeCortical BoneMaleMiceMice, Inbred C57BLMice, KnockoutModels, AnimalOsteogenesisPeriosteumSignal TransductionTransforming Growth Factor beta1Antigens, CDAntigens, Differentiation, MyelomonocyticB7-1 AntigenCD68 MoleculeCD68 protein, mouseTransforming Growth Factor beta1cortical bone formationmacrophagemechanical loadingperiosteum

Identifiers

PMID34854257
PMCPMC8787385
OpenAlexW3217761107

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.