ArticleNature communications2021
Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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37citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- A Systematic Review of Common and Brain-Disease-Specific RNA Editing Alterations Providing Novel Insights into Neurological and Neurodegenerative Disease Manifestations.Biomolecules · 2022Pooled it
- Spatial transcriptomics reveals laminar and cell-type-specific A-to-I RNA editing signatures in the macaque cortex.Nature communications · 2026Article
- Multi-region brain transcriptomes uncover two subtypes of aging individuals with differences in Alzheimer risk and the impact ofiScience · 2026Article
- ADAR-mediated RNA editing in CNS disorders: from pathogenic mechanisms to therapeutic opportunities.Cellular & molecular biology letters · 2026Review
- SIRT5-mediated HSDL2 desuccinylation promotes diabetic-associated cognitive dysfunction via disrupting mitochondrial TRAP1.Cell biology and toxicology · 2026Article
- Integration of aged brain multi-omics reveals cross-system mechanisms underlying Alzheimer's disease heterogeneity.Cell reports · 2026Article
- Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain.Nature communications · 2026Article
- HSDL2 Suppresses Epileptic Seizures Through Phosphorylation-Dependent Modulation of the PSD95-NMDAR Signaling Axis.CNS neuroscience & therapeutics · 2026Article
- RNA-seq variants reveal distinct patterns in the aging epitranscriptome: an in-depth analysis of age-matched Alzheimer's Disease patients and a cognitively normal cohort.bioRxiv : the preprint server for biology · 2026Article
- Construction and analysis of a developmental RNA editome in adipose tissue of Ningxiang pigs.BMC genomics · 2025Article
- RNA modifications, alternative splicing and circular RNA landscape in the mouse brain: inosine and beyond.Scientific reports · 2025Article
- Meta-analysis of genetic regulation of RNA editing in the human brain identifies new genes underlying neurological disease.medRxiv : the preprint server for health sciences · 2025Article
- Integration of aged brain multi-omics reveals cross-system mechanisms underlying Alzheimer's disease heterogeneity.bioRxiv : the preprint server for biology · 2025Article
- ADARs: pleiotropy in function, versatility in application.Nucleic acids research · 2025Review
- Comprehensive characterization of the RNA editing landscape in the human aging brains with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells.bioRxiv : the preprint server for biology · 2025Article
- Integrative bioinformatic approach reveals novel melatonin-related biomarkers for Alzheimer's disease.Scientific reports · 2025Article
- A comprehensive atlas of pig RNA editome across 23 tissues reveals RNA editing affecting interaction mRNA-miRNAs.G3 (Bethesda, Md.) · 2024Article
- Mitochondria-related HSDL2 is a potential biomarker in temporal lobe epilepsy by modulating astrocytic lipid metabolism.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Article
- Bridging the gap: Multi-omics profiling of brain tissue in Alzheimer's disease and older controls in multi-ethnic populations.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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Authors and funding
22 authors at 9 institutions in 2 countries.
Yiyi MaCenter for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th street, New York, NY, 10032, USA.ORCID http://orcid.org/0000-0002-3609-8877
Eric B DammerDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA.ORCID http://orcid.org/0000-0003-2947-7606
Daniel FelskyKrembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-1831-9848
Duc M DuongDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Hans-Ulrich KleinCenter for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th street, New York, NY, 10032, USA.ORCID http://orcid.org/0000-0002-6382-9428
Charles C WhiteCell Circuits Program, Broad Institute, 415 Main street, Cambridge, MA, 02142, USA.
Maotian ZhouDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Benjamin A LogsdonSage Bionetworks, 2901 Third Avenue, Suite 330, Seattle, WA, 98121, USA.ORCID http://orcid.org/0000-0002-0572-2569
Cristin McCabeCell Circuits Program, Broad Institute, 415 Main street, Cambridge, MA, 02142, USA.
Jishu XuRush Alzheimer's Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, 60612, USA.
Minghui WangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0001-9171-4962
Thomas S WingoDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, 30322, USA.ORCID http://orcid.org/0000-0002-7679-6282
James J LahDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Bin ZhangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Julie SchneiderRush Alzheimer's Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, 60612, USA.
Mariet AllenMayo Clinic Florida, Department of Neuroscience, Jacksonville, FL, 32224, USA.
Xue WangMayo Clinic Florida, Department of Health Sciences Research, Jacksonville, FL, 32224, USA.
Nilüfer Ertekin-TanerMayo Clinic Florida, Department of Neuroscience, Jacksonville, FL, 32224, USA.
Nicholas T SeyfriedDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA.ORCID http://orcid.org/0000-0002-4507-624X
Allan I LeveyDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, 30322, USA.ORCID http://orcid.org/0000-0002-3153-502X
David A BennettRush Alzheimer's Disease Center, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, 60612, USA.
Philip L De JagerCenter for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th street, New York, NY, 10032, USA. pld2115@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-8057-2505
Emory University · USBroad Institute · USRush University Medical Center · USColumbia University Irving Medical Center · USIcahn School of Medicine at Mount Sinai · USJacksonville College · USCentre for Addiction and Mental Health · CAFlorida Department of Health · USSage Bionetworks · US
Funding
Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI CAROL A. DERBY · 1985 to 2026
$73.9MSUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MTHE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9MResearch Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$33.5MResearch Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5MIntegrative Network Biology Approaches to Identify, Characterize and Validate Molecular Subtypes in Alzheimer's DiseaseU01AG046170 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WANG, MINGHUI, ZHANG, BIN · 2013 to 2022
$26.0MThe Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI WINGO, THOMAS SPURGEON · 2005 to 2019
$25.7MRisk Factors for Incident Alzheimer's Disease in a Biracial CommunityR01AG011101 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI EVANS, DENIS A · 1993 to 2010
$24.7MIntegrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, FUNK, CORY · 2013 to 2022
$24.6MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MNCRR NIH HHS KL2 RR024151NIA NIH HHS K08 AG034290NIA NIH HHS P01 AG003949NIA NIH HHS P01 AG017216NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG062677NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG025711NIA NIH HHS R01 AG011101NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG018023NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG032990NIA NIH HHS R01 AG036042NIA NIH HHS R01 AG036836NIA NIH HHS R01 AG042210NIA NIH HHS R01 AG043617NIA NIH HHS R01 AG053960NIA NIH HHS R01 AG056533NIA NIH HHS R01 AG057907NIA NIH HHS R01 AG057911NIA NIH HHS R01 AG061796NIA NIH HHS R01 AG061800NIA NIH HHS R56 AG062633NIA NIH HHS RC2 AG036547NIA NIH HHS RF1 AG054014NIA NIH HHS RF1 AG057440NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG046139NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG046161NIA NIH HHS U01 AG046170NIA NIH HHS U01 AG061356NIDA NIH HHS HHSN271201300031CNIEHS NIH HHS U01 ES017155NINDS NIH HHS P30 NS055077NINDS NIH HHS R01 NS080820NINDS NIH HHS U24 NS072026
Abstract
RNA editing is a feature of RNA maturation resulting in the formation of transcripts whose sequence differs from the genome template. Brain RNA editing may be altered in Alzheimer's disease (AD). Here, we analyzed data from 1,865 brain samples covering 9 brain regions from 1,074 unrelated subjects on a transcriptome-wide scale to identify inter-regional differences in RNA editing. We expand the list of known brain editing events by identifying 58,761 previously unreported events. We note that only a small proportion of these editing events are found at the protein level in our proteome-wide validation effort. We also identified the occurrence of editing events associated with AD dementia, neuropathological measures and longitudinal cognitive decline in: SYT11, MCUR1, SOD2, ORAI2, HSDL2, PFKP, and GPRC5B. Thus, we present an extended reference set of brain RNA editing events, identify a subset that are found to be expressed at the protein level, and extend the narrative of transcriptomic perturbation in AD to RNA editing.
Indexed as
RNA EditingTranscriptomeAlzheimer DiseaseAtlases as TopicBrainBrain ChemistryGene Expression ProfilingHumansHydroxysteroid DehydrogenasesMembrane ProteinsMitochondrial ProteinsORAI2 ProteinPhosphofructokinase-1, Type CReceptors, G-Protein-CoupledRNASuperoxide DismutaseGPRC5B protein, humanHSDL2 protein, humanHydroxysteroid DehydrogenasesMCUR1 protein, humanMembrane ProteinsMitochondrial ProteinsORAI2 ProteinORAI2 protein, humanPFKP protein, humanPhosphofructokinase-1, Type CReceptors, G-Protein-CoupledRNASuperoxide DismutaseSuperoxide Dismutase 2SynaptotagminsSYT11 protein, human
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