ReviewDiabetes, metabolic syndrome and obesity : targets and therapy2021
Prediabetes in Adolescents: Prevalence, Management and Diabetes Prevention Strategies.
Review in Diabetes, metabolic syndrome and obesity : targets and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07221045 (PhytoRx Families), which is not on this map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PhytoRx Families: A Pilot Test Study to Address Food Security and Fruit and Vegetable Intake in Rural North Carolina
Who cites it
27 citing papers in PubMed.
- Therapeutic Innovation from Plant-Derived Thai Herbal Extracts: α-Glucosidase Inhibitory Activity, Mechanistic Insights and Formulation Potential of the Selected Thai Rejuvenation Remedy.Life (Basel, Switzerland) · 2026Article
- Prediabetes in children and adolescents in Israel: a large-scale retrospective cohort study.European journal of pediatrics · 2026Article
- Early detection and risk stratification of insulin resistance in children and adolescents with excess weight: a sdLDL/oxLDL-Based model.Clinical and experimental medicine · 2026Article
- Obesity and Cardiometabolic Risk Factors Among Pediatric Patients at a Mississippi Academic Medical Center.American journal of health promotion : AJHP · 2026Observational
- Prevalence and predictors of prediabetes/type 2 diabetes mellitus among adolescents in the United States: NHANES (2021-2023).PLOS global public health · 2026Article
- The Prevalence of and Factors Associated with Prediabetes Among Adolescents in Central Sudan: A Community-Based Cross-Sectional Study.Children (Basel, Switzerland) · 2025Article
- A feasibility study investigating the risk of prediabetes among children in New Zealand.Scientific reports · 2025Article
- Prognostic impact of prediabetes on long-term cardiovascular outcomes in patients under 35 with premature acute myocardial infarction.Diabetology & metabolic syndrome · 2025Article
- Pilot Study: Improving Glycemic Control Among Children and Adolescents With Obesity and Prediabetes With Real-Time Feedback Via Continuous Glucose Monitoring.Diabetes spectrum : a publication of the American Diabetes Association · 2025Article
- The role of School-Based Health Centers in adolescent well-being: a call for action.Frontiers in public health · 2025Article
- Prevalence of and factors associated with pre-diabetes among adolescents in Eastern Sudan: a community-based cross-sectional study.BMJ open · 2024Article
- A clinician's guide to effects of obesity on childhood asthma and into adulthood.Expert review of respiratory medicine · 2024Review
- Prediabetes in children and adolescents: A ticking bomb!World journal of clinical pediatrics · 2024Article
- Effect of eight-week high-intensity interval training versus moderate-intensity continuous training programme on body composition, cardiometabolic risk factors in sedentary adolescents.Frontiers in physiology · 2024Article
- Prevalence of prediabetes by the fasting plasma glucose and HbA1c screening criteria among the children and adolescents of Shenzhen, China.Frontiers in endocrinology · 2024Article
- Less common forms of diabetes in young population.Pediatric endocrinology, diabetes, and metabolism · 2024Review
- Postprandial Metabolite Profiles and Risk of Prediabetes in Young People: A Longitudinal Multicohort Study.Diabetes care · 2024Article
- Prediabetes in children and adolescents: An updated review.World journal of clinical pediatrics · 2023Review
- Risk Factors for Progression to Type 2 Diabetes in a Pediatric Prediabetes Clinic Population.Journal of the Endocrine Society · 2023Article
- Ethnicity/race, parent educational attainment, and obesity associated with prediabetes in children.Nutrition & diabetes · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ongoing obesity epidemic in children and adolescents has greatly increased the prevalence of related comorbidities. Prediabetes is defined based on levels of fasting glucose, oral glucose tolerance tests or hemoglobin A1c, that are intermediate between normal levels and thresholds that define type 2 diabetes mellitus (T2DM). As such, prediabetes represents a sign of early pathophysiology preceding T2DM development. Recent analyses of data from US adolescents estimate prediabetes to be present in 4-23% of adolescents, depending on criteria used, with other studies finding an 8% risk of progression from prediabetes to T2DM over a 3-year period. These data support the importance of intervention to avoid long-term sequelae, focusing on reducing degree of obesity and insulin resistance. Lifestyle modification, with increases in physical activity and dietary improvements, remains the first-line approach. Other interventions are based on additional long-term risks and range from metformin treatment for more moderate cases of prediabetes to bariatric surgery for adolescents with severe obesity and comorbidities. As data accumulate regarding sequelae of T2DM in adolescents, there remains a critical need for prevention of obesity and T2DM throughout childhood, and prediabetes should be a trigger for improving this risk profile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.