ArticleFrontiers in integrative neuroscience2021
The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers.
Article in Frontiers in integrative neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Sensory-movement underpinnings of lifelong neurodivergence: getting a grip on autism.Frontiers in integrative neuroscience · 2025Article
- Integrative mindfulness-based infant parenting program: theoretical foundations and a novel intervention protocol.Frontiers in psychology · 2025Review
- Brainstem and Deep Gray Nuclei Modulate Brain Network Efficiency in Low-risk Term Newborns.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Role of autonomic, nociceptive, and limbic brainstem nuclei in core autism features.Autism research : official journal of the International Society for Autism Research · 2024Article
- Interoception in Autism: A Narrative Review of Behavioral and Neurobiological Data.Psychology research and behavior management · 2024Review
- Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis.Biology open · 2023Article
- Spasm of Near Reflex in a Patient with Autism Spectrum Disorder: A Case Report.Reports (MDPI) · 2023Article
- Valproic acid affects neurogenesis during early optic tectum development in zebrafish.Biology open · 2023Article
- Simulating developmental diversity: Impact of neural stochasticity on atypical flexibility and hierarchy.Frontiers in psychiatry · 2023Article
- When the Mind Comes to Live Inside the Body: The Ontogeny of the Perceptual Control Clock.Current neuropharmacology · 2023Article
- Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children.Molecular autism · 2022Article
- The "Primitive Brain Dysfunction" Theory of Autism: The Superior Colliculus Role.Frontiers in integrative neuroscience · 2022Article
- Hyper and hypo attention networks activations affect social development in children with autism spectrum disorder.Frontiers in human neuroscience · 2022Article
- Wired to Connect: The Autonomic Socioemotional Reflex Arc.Frontiers in psychology · 2022Review
- Article
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Authors and funding
2 authors.
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Abstract
Autism spectrum disorders (ASD) have long-term implications on functioning at multiple levels. In this perspective, we offer a brainstem-informed autism framework (BIAF) that traces the protracted neurobehavioral manifestations of ASD to early life brainstem dysfunctions. Early life brainstem-mediated markers involving functions of autonomic/arousal regulation, sleep-wake homeostasis, and sensorimotor integration are delineated. Their possible contributions to the early identification of susceptible infants are discussed. We suggest that the BIAF expands our multidimensional understanding of ASD by focusing on the early involvement of brainstem systems. Importantly, we propose an integrated BIAF screener that brings about the prospect of a sensitive and reliable early life diagnostic scheme for weighing the risk for ASD. The BIAF screener could provide clinicians substantial gains in the future and may carve customized interventions long before the current DSM ASD phenotype is manifested using dyadic co-regulation of brainstem-informed autism markers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.