Evidence map›Paper›PMID 34859913›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2022

Guanylyl cyclase-A phosphorylation decreases cardiac hypertrophy and improves systolic function in male, but not female, mice.

Brandon M Wagner, Jerid W Robinson, Chastity L Healy, Madeline Gauthier, Deborah M Dickey, Siu-Pok Yee, John W Osborn, Timothy D O'Connell, Lincoln R Potter

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Sex-based differences in metabolic protection by the ANP genetic variant rs5068 in the general population.American journal of physiology. Heart and circulatory physiology · 2023
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Brandon M WagnerDepartment of Integrative Biology and Physiology, University of Minnesota, Medical School, Minneapolis, Minnesota, USA.
Jerid W RobinsonDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Medical School, Minneapolis, Minnesota, USA.
Chastity L HealyDepartment of Integrative Biology and Physiology, University of Minnesota, Medical School, Minneapolis, Minnesota, USA.
Madeline GauthierDepartment of Integrative Biology and Physiology, University of Minnesota, Medical School, Minneapolis, Minnesota, USA.
Deborah M DickeyDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Medical School, Minneapolis, Minnesota, USA.
Siu-Pok YeeDepartment of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut, USA.
John W OsbornDepartment of Surgery, University of Minnesota, Medical School, Minneapolis, Minnesota, USA.
Timothy D O'ConnellDepartment of Integrative Biology and Physiology, University of Minnesota, Medical School, Minneapolis, Minnesota, USA.
Lincoln R PotterDepartment of Integrative Biology and Physiology, University of Minnesota, Medical School, Minneapolis, Minnesota, USA.
University of Minnesota Medical Center · USUConn Health · US

Funding

TRAINING GRANT IN DIABETES, ENDOCRINOLOGY, &METABOLISMT32DK007203 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LISA Senye CHOW, Douglas G Mashek · 1986 to 2026
$4.3M
Free fatty acid receptor 4 cardioprotective effects in cardiac ischemic injuryR01HL152215 · NHLBI · UNIVERSITY OF MINNESOTA · PI O'CONNELL, TIMOTHY D, SHEARER, GREGORY C · 2020 to 2024
$3.4M
Eicosapentaenoic acid activation of free fatty acid receptor 4 prevents fibrosis, microvascular rarefaction, and diastolic dysfunction; implications for heart failure preserved ejection fractionR01HL130099 · NHLBI · UNIVERSITY OF MINNESOTA · PI O'CONNELL, TIMOTHY D, SHEARER, GREGORY C · 2016 to 2019
$1.5M
Regulation of guanylyl cyclase A and B by hormones, ATP and phosphorylationR01GM098309 · NIGMS · UNIVERSITY OF MINNESOTA · PI POTTER, LINCOLN ROSS · 2013 to 2016
$1.1M
NHLBI NIH HHS R01 HL130099NHLBI NIH HHS R01 HL152215NIDDK NIH HHS T32 DK007203NIGMS NIH HHS R01 GM098309
6 · The paper itself

Abstract

Atrial natriuretic peptide (NP) and BNP increase cGMP, which reduces blood pressure and cardiac hypertrophy by activating guanylyl cyclase (GC)-A, also known as NPR-A or Npr1. Although GC-A is highly phosphorylated, and dephosphorylation inactivates the enzyme, the significance of GC-A phosphorylation to heart structure and function remains unknown. To identify in vivo processes that are regulated by GC-A phosphorylation, we substituted glutamates for known phosphorylation sites to make GC-A

Indexed as

CardiomegalyMAP Kinase Signaling SystemPhosphorylationReceptors, Atrial Natriuretic FactorSex CharacteristicsAnimalsFemaleMaleMiceMice, Transgenicatrial natriuretic factor receptor AReceptors, Atrial Natriuretic Factorcardiac hypertrophyextracellular-regulated kinaseguanylyl cyclasehypertensionnatriuretic peptide

Identifiers

PMID34859913
PMCPMC8826535
OpenAlexW3215088802

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.