ArticleTrials2021
Unification of Treatments and Interventions for Tinnitus Patients (UNITI): a study protocol for a multi-center randomized clinical trial.
Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04663828 (UNification of Treatments and Interventions for TInnitus Patients - Randomized Clinical Trial), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
UNification of Treatments and Interventions for TInnitus Patients - Randomized Clinical Trial (UNITI-RCT)
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Single versus combination treatment in tinnitus: an international, multicentre, parallel-arm, superiority, randomised controlled trial.Nature communications · 2025Trial
- Estimation of Minimal Clinically Important Difference for Tinnitus Handicap Inventory and Tinnitus Functional Index.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Trial
- Trial
- Uncovering latent trajectories of daily tinnitus symptoms through app-based monitoring during treatment.Internet interventions · 2026Article
- Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects.Frontiers in aging neuroscience · 2026Review
- Brief Acoustic Tinnitus Suppression as a Diagnostic Procedure in Clinical Routine: Feasibility and Results.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Somatosensory Intervention Targeting Temporomandibular Disorders and Awake Bruxism Positively Impacts Subjective Tinnitus.Audiology research · 2025Article
- Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data.NPJ digital medicine · 2025Article
- The Out-of-pocket Expenses of People With Tinnitus in Europe.Journal of epidemiology · 2024Article
- The Current State of Tinnitus Diagnosis and Treatment: a Multidisciplinary Expert Perspective.Journal of the Association for Research in Otolaryngology : JARO · 2024Review
- Cognitive Screening and Hearing Assessment in Patients With Chronic Tinnitus.Clinical and experimental otorhinolaryngology · 2024Article
- Development of Machine-Learning Models for Tinnitus-Related Distress Classification Using Wavelet-Transformed Auditory Evoked Potential Signals and Clinical Data.Journal of clinical medicine · 2023Article
- Tinnitus Guidelines and Their Evidence Base.Journal of clinical medicine · 2023Article
- Development and Evaluation of Automated Tools for Auditory-Brainstem and Middle-Auditory Evoked Potentials Waves Detection and Annotation.Brain sciences · 2022Article
- Smartphone-Guided Educational Counseling and Self-Help for Chronic Tinnitus.Journal of clinical medicine · 2022Article
- Experience of tinnitus in adults who have severe-to-profound hearing loss: A scoping review.Frontiers in neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 11 institutions in 6 countries.
Funding
Abstract
backgroundTinnitus represents a relatively common condition in the global population accompanied by various comorbidities and severe burden in many cases. Nevertheless, there is currently no general treatment or cure, presumable due to the heterogeneity of tinnitus with its wide variety of etiologies and tinnitus phenotypes. Hence, most treatment studies merely demonstrated improvement in a subgroup of tinnitus patients. The majority of studies are characterized by small sample sizes, unstandardized treatments and assessments, or applications of interventions targeting only a single organ level. Combinatory treatment approaches, potentially targeting multiple systems as well as treatment personalization, might provide remedy and enhance treatment responses. The aim of the present study is to systematically examine established tinnitus therapies both alone and in combination in a large sample of tinnitus patients. Further, it wants to provide the basis for personalized treatment approaches by evaluating a specific decision support system developed as part of an EU-funded collaborative project (Unification of treatments and interventions for tinnitus patients; UNITI project). METHODS/STUDY
designThis is a multi-center parallel-arm randomized clinical trial conducted at five different clinical sites over the EU. The effect of four different tinnitus therapy approaches (sound therapy, structured counseling, hearing aids, cognitive behavioral therapy) applied over a time period of 12 weeks as a single or rather a combinatory treatment in a total number of 500 chronic tinnitus patients will be investigated. Assessments and interventions are harmonized over the involved clinical sites. The primary outcome measure focuses on the domain tinnitus distress assessed via the Tinnitus Handicap Inventory. DISCUSSION: Results and conclusions from the current study might not only provide an essential contribution to combinatory and personalized treatment approaches in tinnitus but could also provide more profound insights in the heterogeneity of tinnitus, representing an important step towards a cure for tinnitus.
trial registrationClinicalTrials.gov NCT04663828 . Registered on 11 December 2020.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.