Evidence map›Paper›PMID 34867270›Full record

ArticleFrontiers in aging neuroscience2021

Myo-Inositol Levels in the Dorsal Hippocampus Serve as Glial Prognostic Marker of Mild Cognitive Impairment in Mice.

Tim Ebert, Daniel E Heinz, Suellen Almeida-Corrêa, Renata Cruz, Frederik Dethloff, Tibor Stark, Thomas Bajaj, Oriana M Maurel, Fabiola M Ribeiro, Silvio Calcagnini and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. The human milk componentProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Tim EbertResearch Group Neuronal Plasticity, Max Planck Institute of Psychiatry, Munich, Germany.
Daniel E HeinzResearch Group Neuronal Plasticity, Max Planck Institute of Psychiatry, Munich, Germany.
Suellen Almeida-CorrêaResearch Group Neuronal Plasticity, Max Planck Institute of Psychiatry, Munich, Germany.
Renata CruzResearch Group Neuronal Plasticity, Max Planck Institute of Psychiatry, Munich, Germany.
Frederik DethloffProteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich, Germany.
Tibor StarkResearch Group Neuronal Plasticity, Max Planck Institute of Psychiatry, Munich, Germany.
Thomas BajajResearch Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.
Oriana M MaurelResearch Group Neuronal Plasticity, Max Planck Institute of Psychiatry, Munich, Germany.
Fabiola M RibeiroResearch Group Neuronal Plasticity, Max Planck Institute of Psychiatry, Munich, Germany.
Silvio CalcagniniResearch Group Neuronal Plasticity, Max Planck Institute of Psychiatry, Munich, Germany.
Kathrin HafnerDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Nils C GassenResearch Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany.
Christoph W TurckProteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich, Germany.
Benoit BoulatScientific Core Unit "Neuroimaging", Max Planck Institute of Psychiatry, Munich, Germany.
Michael CzischScientific Core Unit "Neuroimaging", Max Planck Institute of Psychiatry, Munich, Germany.
Carsten T WotjakResearch Group Neuronal Plasticity, Max Planck Institute of Psychiatry, Munich, Germany.
Max Planck Institute of Psychiatry · DEUniversity Hospital Bonn · DEBoehringer Ingelheim (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dementia is a devastating age-related disorder. Its therapy would largely benefit from the identification of susceptible subjects at early, prodromal stages of the disease. To search for such prognostic markers of cognitive impairment, we studied spatial navigation in male BALBc vs. B6N mice in combination with

Indexed as

astrocytesbiomarkergliaMCImicrogliaMRSmyo-inositolspatial memory

Identifiers

PMID34867270
PMCPMC8633395
OpenAlexW3212196891

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.