Evidence map›Paper›PMID 34867295›Full record

ReviewFrontiers in aging neuroscience2021

The Interplay of the Unfolded Protein Response in Neurodegenerative Diseases: A Therapeutic Role of Curcumin.

Sitabja Mukherjee, Awdhesh Kumar Mishra, G D Ghouse Peer, Sali Abubaker Bagabir, Shafiul Haque, Ramendra Pati Pandey, V Samuel Raj, Neeraj Jain, Atul Pandey, Santosh Kumar Kar

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Ameliorative Effect of Ethanolic Extract ofPharmaceuticals (Basel, Switzerland) · 2023
    Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 6 countries.

Sitabja MukherjeeSchool of Biotechnology, KIIT University, Bhubaneswar, India.
Awdhesh Kumar MishraDepartment of Biotechnology, Yeungnam University, Gyeongsan, South Korea.
G D Ghouse PeerDepartment of Biotechnology, Sri Ramaswamy Memorial (SRM) University, Sonepat, India.
Sali Abubaker BagabirDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Shafiul HaqueResearch and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia.
Ramendra Pati PandeyDepartment of Biotechnology, Sri Ramaswamy Memorial (SRM) University, Sonepat, India.
V Samuel RajDepartment of Biotechnology, Sri Ramaswamy Memorial (SRM) University, Sonepat, India.
Neeraj JainDivision of Cancer Biology, Council of Scientific and Industrial Research (CSIR)-Central Drug Research Institute, Lucknow, India.
Atul PandeyDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, United States.
Santosh Kumar KarNano Herb Research Laboratory, Kalinga Institute of Industrial Technology (KIIT) Technology Business Incubator, KIIT University, Bhubaneswar, India.
SRM University · INJazan University · SAKIIT University · INCentral Drug Research Institute · INUniversity of Michigan–Ann Arbor · USYeungnam University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal accumulation of misfolded proteins in the endoplasmic reticulum and their aggregation causes inflammation and endoplasmic reticulum stress. This promotes accumulation of toxic proteins in the body tissues especially brain leading to manifestation of neurodegenerative diseases. The studies suggest that deregulation of proteostasis, particularly aberrant unfolded protein response (UPR) signaling, may be a common morbific process in the development of neurodegeneration. Curcumin, the mixture of low molecular weight polyphenolic compounds from turmeric,

Indexed as

Alzheimer’s diseasecell deathcurcuminER stressneurodegenarationParkinson’s diseaseROS—reactive oxygen speciesunfolded protein response

Identifiers

PMID34867295
PMCPMC8640216
OpenAlexW3215844326

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.