Evidence map›Paper›PMID 34867992›Full record

ArticleFrontiers in immunology2021

Co-Exposure of Cardiomyocytes to IFN-γ and TNF-α Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease Cardiomyopathy.

João Paulo Silva Nunes, Pauline Andrieux, Pauline Brochet, Rafael Ribeiro Almeida, Eduardo Kitano, André Kenji Honda, Leo Kei Iwai, Débora Andrade-Silva, David Goudenège, Karla Deysiree Alcântara Silva and 17 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 61 citations in OpenAlex.

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  10. Interferon gamma signaling drives cardiac metabolic rewiring.bioRxiv : the preprint server for biology · 2025
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  19. Small Extracellular Vesicles from Breast Cancer Cells Induce Cardiotoxicity.International journal of molecular sciences · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 11 institutions in 4 countries.

João Paulo Silva NunesLaboratory of Immunology, Heart Institute (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Pauline AndrieuxINSERM, UMR_1090, Aix Marseille Université, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa, Marseille, France.
Pauline BrochetINSERM, UMR_1090, Aix Marseille Université, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa, Marseille, France.
Rafael Ribeiro AlmeidaLaboratory of Immunology, Heart Institute (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Eduardo KitanoLaboratory of Immunology, Heart Institute (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
André Kenji HondaLaboratory of Immunology, Heart Institute (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Leo Kei IwaiLaboratório Especial de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling (CeTICS), Instituto Butantan, São Paulo, Brazil.
Débora Andrade-SilvaLaboratório Especial de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling (CeTICS), Instituto Butantan, São Paulo, Brazil.
David GoudenègeDepartment of Biochemistry and Genetics, University Hospital of Angers, Angers, France.
Karla Deysiree Alcântara SilvaLaboratory of Immunology, Heart Institute (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Raquel de Souza VieiraLaboratory of Immunology, Heart Institute (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Débora LevyLaboratory of Immunology, Heart Institute (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Sergio Paulo BydlowskiLaboratory of Immunology, Heart Institute (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Frédéric GallardoINSERM, UMR_1090, Aix Marseille Université, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa, Marseille, France.
Magali TorresINSERM, UMR_1090, Aix Marseille Université, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa, Marseille, France.
Edimar Alcides BocchiHeart Failure Team, Heart Institute (Incor) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Miguel ManoFunctional Genomics and RNA-based Therapeutics Laboratory, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal.
Ronaldo Honorato Barros SantosDivision of Surgery, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil.
Fernando BacalDivision of Surgery, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil.
Pablo PomerantzeffDivision of Surgery, Heart Institute, School of Medicine, University of São Paulo, São Paulo, Brazil.
Francisco Rafael Martins LaurindoLaboratory of Vascular Biology, Heart Institute of the School of Medicine, University of São Paulo, São Paulo, Brazil.
Priscila Camillo TeixeiraTranslational Research Sciences, Pharma Research and Early Development F. Hoffmann-La Roche, Basel, Switzerland.
Helder I NakayaHospital Israelita Albert Einstein, São Paulo, Brazil.
Jorge KalilLaboratory of Immunology, Heart Institute (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Vincent ProcaccioMitoLab, UMR CNRS 6015-INSERM U1083, Université d'Angers, Angers, France.
Christophe ChevillardINSERM, UMR_1090, Aix Marseille Université, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa, Marseille, France.
Edecio Cunha-NetoLaboratory of Immunology, Heart Institute (Incor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRTheories and Approaches of Genomic Complexity · FRUniversidade de São Paulo · BRInstituto Butantan · BRAix-Marseille Université · FRCentre National de la Recherche Scientifique · FRHospital Israelita Albert Einstein · BRInserm · FRRoche (Switzerland) · CHUniversité d'Angers · FRUniversity of Coimbra · PT

Funding

Sao Paulo-Minas Gerais Tropical Medicine Research Center for Chagas Disease Biomarker DiscoveryU19AI098461 · NIAID · FUNDACAO FACULDADE DE MEDICINA · PI PEREIRA, ALEXANDRE DA COSTA · 2017 to 2021
$2.1M
Sao Paulo- MInas Gerais Neglected Tropical Disease Research Center for BiomarkerP50AI098461 · NIAID · FUNDACAO FACULDADE DE MEDICINA · PI SABINO, ESTER CERDEIRA · 2012 to 2016
$1.5M
NIAID NIH HHS P50 AI098461NIAID NIH HHS U19 AI098461
6 · The paper itself

Abstract

Infection by the protozoan

Indexed as

AdolescentAdultAgedChagas CardiomyopathyChildFemaleHumansInterferon-gammaMaleMiddle AgedMitochondriaMyocytes, CardiacOxidative StressTumor Necrosis Factor-alphaYoung AdultInterferon-gammaTumor Necrosis Factor-alphachronic Chagas disease cardiomyopathyenergy metabolisminterferon gammamitochondriamitochondrial dysfunction

Identifiers

PMID34867992
PMCPMC8632642
OpenAlexW3212372018

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.