Evidence map›Paper›PMID 34868042›Full record

ReviewFrontiers in immunology2021

COVID-19, Pre-Eclampsia, and Complement System.

Chiara Agostinis, Alessandro Mangogna, Andrea Balduit, Azin Aghamajidi, Giuseppe Ricci, Uday Kishore, Roberta Bulla

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Thromboembolic Events in the Era of COVID-19: A Detailed Narrative Review.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Review
  6. Preeclampsia in the Context of COVID-19: Mechanisms, Pathophysiology, and Clinical Outcomes.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Impact of Covid-19 on risk of severe maternal morbidity.Critical care (London, England) · 2023
    Article
  13. Review
  14. Review
  15. HELLP syndrome and COVID-19: A minor revision of a possible new "COVID-19-linked HELLP-like syndrome".European journal of obstetrics, gynecology, and reproductive biology · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Mild or Moderate COVID-19 during Pregnancy Does Not Affect the Content of CD34Bulletin of experimental biology and medicine · 2022
    Article
  20. Molecular Advances in Preeclampsia and HELLP Syndrome.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Chiara AgostinisInstitute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo, Trieste, Italy.
Alessandro MangognaInstitute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo, Trieste, Italy.
Andrea BalduitDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Azin AghamajidiDepartment of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Giuseppe RicciInstitute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo, Trieste, Italy.
Uday KishoreBiosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, United Kingdom.
Roberta BullaDepartment of Life Sciences, University of Trieste, Trieste, Italy.
IRCCS Materno Infantile Burlo Garofolo · ITUniversity of Trieste · ITBrunel University of London · GBIran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 is characterized by virus-induced injury leading to multi-organ failure, together with inflammatory reaction, endothelial cell (EC) injury, and prothrombotic coagulopathy with thrombotic events. Complement system (C)

Indexed as

Complement Inactivator ProteinsComplement System ProteinsCOVID-19COVID-19 Drug TreatmentEndotheliumFemaleHumansPre-EclampsiaPregnancyPregnancy Complications, InfectiousSARS-CoV-2ThrombosisComplement Inactivator ProteinsComplement System Proteinscomplement systemCOVID-19pre-eclampsiapregnancySARS-CoV-2

Identifiers

PMID34868042
PMCPMC8635918
OpenAlexW3214342400

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.