Evidence map›Paper›PMID 34868246›Full record

ArticleFrontiers in genetics2021

Novel LAT Pathogenic Variants in a POI Family and Its Role in the Ovary.

Kun Chu, Yi He, Ziyuan Li, Zhongxin Jiang, Liang Wang, Yixuan Ji, Xiang Wang, Wenjuan Pang, Ningxia Sun, Fu Yang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Genetic insights into the complexity of premature ovarian insufficiency.Reproductive biology and endocrinology : RB&E · 2024
    Review
  3. Article
  4. Selected Genetic Factors Associated with Primary Ovarian Insufficiency.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Kun ChuCenter of Reproductive Medicine, Shanghai Key Laboratory of Embryo Original Diseases, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yi HeCenter of Reproductive Medicine, Shanghai Key Laboratory of Embryo Original Diseases, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ziyuan LiCenter of Reproductive Medicine, Changzheng Hospital, Naval Medical University, Shanghai, China.
Zhongxin JiangCenter of Reproductive Medicine, Changzheng Hospital, Naval Medical University, Shanghai, China.
Liang WangCenter of Reproductive Medicine, Changzheng Hospital, Naval Medical University, Shanghai, China.
Yixuan JiCenter of Reproductive Medicine, Changzheng Hospital, Naval Medical University, Shanghai, China.
Xiang WangDepartment of Obstetrics and Gynecology, No. 905 Hospital of PLA Navy, Shanghai, China.
Wenjuan PangCenter of Reproductive Medicine, Changzheng Hospital, Naval Medical University, Shanghai, China.
Ningxia SunCenter of Reproductive Medicine, Changzheng Hospital, Naval Medical University, Shanghai, China.
Fu YangDepartment of Medical Genetics, Naval Medical University, Shanghai, China.
Wen LiCenter of Reproductive Medicine, Shanghai Key Laboratory of Embryo Original Diseases, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Changzheng Hospital · CNShanghai Jiao Tong University · CNInternational Peace Maternity & Child Health Hospital · CNPLA Navy General Hospital · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Premature ovarian insufficiency (POI) affects about 1% of women under 40 years and leads most often to definitive infertility with adverse health outcomes. Genetic factor has been reported to play an important role in POI. However, the genetic etiology remains unknown in the majority of the POI patients. Whole-exome sequencing and variant analysis were carried out in a POI pedigree.

Indexed as

genetic varaiantgenetic variantsgranulosa cellprimary ovarian insufficiencythe linker for the activation of T cellswhole-exome sequencing

Identifiers

PMID34868246
PMCPMC8640088
OpenAlexW3215460455

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.