Evidence map›Paper›PMID 34868919›Full record

ArticleFrontiers in oncology2021

Gene Co-Expression in Breast Cancer: A Matter of Distance.

Alfredo González-Espinoza, Jose Zamora-Fuentes, Enrique Hernández-Lemus, Jesús Espinal-Enríquez

Abstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Loss of long-range co-expression is a common feature in cancer.NPJ systems biology and applications · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alfredo González-EspinozaDepartment of Biology, University of Pennsylvania, Philadelphia, PA, United States.
Jose Zamora-FuentesComputational Genomics Division, National Institute of Genomic Medicine, Mexico City, Mexico.
Enrique Hernández-LemusComputational Genomics Division, National Institute of Genomic Medicine, Mexico City, Mexico.
Jesús Espinal-EnríquezComputational Genomics Division, National Institute of Genomic Medicine, Mexico City, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene regulatory and signaling phenomena are known to be relevant players underlying the establishment of cellular phenotypes. It is also known that such regulatory programs are disrupted in cancer, leading to the onset and development of malignant phenotypes. Gene co-expression matrices have allowed us to compare and analyze complex phenotypes such as breast cancer (BrCa) and their control counterparts. Global co-expression patterns have revealed, for instance, that the highest gene-gene co-expression interactions often occur between genes from the same chromosome (

Indexed as

breast cancer molecular subtypesco-expression matriceseigenvalue decompositiongene co-expression clusteringloss of long-distance co-expression

Identifiers

PMID34868919
PMCPMC8636045

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.