Evidence map›Paper›PMID 34870514›Full record

ArticleJournal of empirical research on human research ethics : JERHRE

Stakeholder Perspectives on Returning Nonactionable Apolipoprotein L1 (APOL1) Genetic Results to African American Research Participants.

Kathleen M West, Kerri L Cavanaugh, Erika Blacksher, Stephanie M Fullerton, Ebele M Umeukeje, Bessie Young, Wylie Burke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of empirical research on human research ethics : JERHRE. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Race, Ancestry, and Genetic Risk for Kidney Failure.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022
    Article
  3. Kidney medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kathleen M West7284University of Washington, Seattle, WA, USA.ORCID 0000-0002-0770-5316
Kerri L Cavanaugh12328Vanderbilt University Medical Center, Nashville, TN, USA.
Erika Blacksher7284University of Washington, Seattle, WA, USA.ORCID 0000-0002-0098-7154
Stephanie M Fullerton7284University of Washington, Seattle, WA, USA.
Ebele M Umeukeje12328Vanderbilt University Medical Center, Nashville, TN, USA.
Bessie Young7284University of Washington, Seattle, WA, USA.
Wylie Burke7284University of Washington, Seattle, WA, USA.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Community-Based Evaluation of APOL1 Genetic Testing in African AmericansR01HG007879 · NHGRI · UNIVERSITY OF WASHINGTON · PI BURKE, WYLIE G., YOUNG, BESSIE ANN · 2015 to 2017
$2.1M
Patient-centered Approach To Improving Dialysis Adherence in African AmericansK23DK114566 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI UMEUKEJE, EBELE M · 2018 to 2022
$929k
MOVE: MOtiVational Strategies To Empower African Americans To Improve Dialysis AdherenceR03DK129626 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI UMEUKEJE, EBELE M · 2021 to 2022
$260k
NCATS NIH HHS UL1 TR002243NHGRI NIH HHS R01 HG007879NIDDK NIH HHS K23 DK114566NIDDK NIH HHS R03 DK129626
6 · The paper itself

Abstract

The ethics of returning nonactionable genetic research results to individuals are unclear. Apolipoprotein L1 (

Indexed as

Apolipoprotein L1Kidney TransplantationBlack or African AmericanGenetic Predisposition to DiseaseGenetic TestingHumansAPOL1 protein, humanApolipoprotein L1apolipoprotein L1chronic kidney diseaseend-stage kidney diseasegenetic researchreturn of resultsrisks/benefitsstakeholder views

Identifiers

PMID34870514
PMCPMC9053332

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.