Evidence map›Paper›PMID 34870705›Full record

ArticleJournal of cell science2021

Cargo sorting at the trans-Golgi network at a glance.

Charlotte Ford, Anup Parchure, Julia von Blume, Christopher G Burd

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
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  15. Article
  16. Cells · 2023
    Review
  17. Review
  18. Article
  19. CaAdvances in experimental medicine and biology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Charlotte FordDepartment of Cell Biology, Yale School of Medicine, Yale University, New Haven, CT 06520, USA.
Anup ParchureDepartment of Cell Biology, Yale School of Medicine, Yale University, New Haven, CT 06520, USA.
Julia von BlumeDepartment of Cell Biology, Yale School of Medicine, Yale University, New Haven, CT 06520, USA.
Christopher G BurdDepartment of Cell Biology, Yale School of Medicine, Yale University, New Haven, CT 06520, USA.ORCID 0000-0003-1831-8706
Yale University · US

Funding

PtdIns 4-Kinase Regulation of Protein Sorting in the Golgi ApparatusR01GM095766 · NIGMS · YALE UNIVERSITY · PI BURD, CHRISTOPHER G · 2011 to 2021
$2.9M
Sorting and Trafficking in the Endosomal SystemR37GM061221 · NIGMS · YALE UNIVERSITY · PI BURD, CHRISTOPHER G · 2017 to 2021
$2.0M
Mechanism of secretory cargo sorting at the trans-Golgi Network (TGN)R35GM149293 · NIGMS · YALE UNIVERSITY · PI Julia von Blume · 2023 to 2026
$1.6M
Mechanism of secretory cargo export from the TGNR01GM134083 · NIGMS · YALE UNIVERSITY · PI VON BLUME, JULIA · 2019 to 2022
$1.5M
NIGMS NIH HHS R01 GM095766NIGMS NIH HHS R01 GM134083NIGMS NIH HHS R35 GM149293NIGMS NIH HHS R37 GM061221NIH HHS GM060221
6 · The paper itself

Abstract

The Golgi functions principally in the biogenesis and trafficking of glycoproteins and lipids. It is compartmentalized into multiple flattened adherent membrane sacs termed cisternae, which each contain a distinct repertoire of resident proteins, principally enzymes that modify newly synthesized proteins and lipids sequentially as they traffic through the stack of Golgi cisternae. Upon reaching the final compartments of the Golgi, the trans cisterna and trans-Golgi network (TGN), processed glycoproteins and lipids are packaged into coated and non-coated transport carriers derived from the trans Golgi and TGN. The cargoes of clathrin-coated vesicles are chiefly residents of endo-lysosomal organelles, while uncoated carriers ferry cargo to the cell surface. There are outstanding questions regarding the mechanisms of protein and lipid sorting within the Golgi for export to different organelles. Nonetheless, conceptual advances have begun to define the key molecular features of cargo clients and the mechanisms underlying their sorting into distinct export pathways, which we have collated in this Cell Science at a Glance article and the accompanying poster.

Indexed as

Golgi Apparatustrans-Golgi NetworkCell MembraneClathrin-Coated VesiclesHumansProtein TransportCalciumClathrinEpithelial cellsGlycoproteinGolgiLipidsSecretion

Identifiers

PMID34870705
PMCPMC8714066
OpenAlexW4200048470

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.