Evidence map›Paper›PMID 34871429›Full record

ArticleThe Journal of nutrition2022

Habitual Intake of Marine-Derived n-3 PUFAs is Inversely Associated with a Cardiometabolic Inflammatory Profile in Yup'ik Alaska Native People.

Bert B Boyer, Scarlett E Hopkins, Howard W Wiener, Jonathan Q Purnell, Diane M O'Brien, Cindy X Zhang, Joseph E Aslan, Theresa Aliwarga, Jeremy J Pomeroy, Kenneth E Thummel and 1 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Bert B BoyerDepartment of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.
Scarlett E HopkinsDepartment of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.
Howard W WienerDepartment of Statistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Jonathan Q PurnellDepartment of Medicine, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0001-5505-6333
Diane M O'BrienDepartment of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, AK, USA.ORCID 0000-0001-5807-9661
Cindy X ZhangDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Joseph E AslanDepartment of Medicine, Oregon Health & Science University, Portland, OR, USA.
Theresa AliwargaDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Jeremy J PomeroyClinical Research Center, Marshfield Clinic, Marshfield, WI, USA.
Kenneth E ThummelDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7799-3739
Hemant K TiwariDepartment of Statistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Oregon Health & Science University · USUniversity of Washington · USUniversity of Alabama at Birmingham · USMarshfield Clinic · USUniversity of Alaska Fairbanks · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Pilot Project ProgramP30GM103325 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI O'BRIEN, DIANE MARIE · 2012 to 2016
$5.3M
EPIGENOME MODIFICATION BY A DIETARY PATTERN RICH IN POLYUNSATURATED FATTY ACIDSR01DK104347 · NIDDK · UNIVERSITY OF ALASKA FAIRBANKS · PI ABSHER, DEVIN MICHAEL, BOYER, BERT BRANDON · 2016 to 2019
$2.5M
Pathway Maps of Platelet Phenotype and FunctionR01HL146549 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ASLAN, JOSEPH E · 2019 to 2023
$2.5M
Epigenome modification by a dietary pattern rich in polyunsaturated fatty acidsR01DK112358 · NIDDK · UNIVERSITY OF ALASKA FAIRBANKS · PI ABSHER, DEVIN MICHAEL, BOYER, BERT BRANDON · 2017 to 2020
$575k
NHLBI NIH HHS R01 HL146549NIDDK NIH HHS R01 DK104347NIDDK NIH HHS R01 DK112358NIGMS NIH HHS P30 GM103325NIH HHS P51 OD011092
6 · The paper itself

Abstract

backgroundThe relationship between dietary n-3 PUFAs and the prevention of cardiometabolic diseases, including type 2 diabetes, is unresolved. Examination of the association between n-3 PUFAs and chronic low-grade inflammation in a population where many individuals have had an extremely high intake of marine mammals and fish throughout their lifespan may provide important clues regarding the impact of n-3 PUFAs on health.

objectivesThe aim of this study was to explore associations between concentrations of n-3 PUFAs resulting from habitual intake of natural food sources high in fish and marine mammals with immune biomarkers of metabolic inflammation and parameters of glucose regulation.

methodsA total of 569 Yup'ik Alaska Native adults (18-87 years old) were enrolled in this cross-sectional study between December 2016 and November 2019. The RBC nitrogen isotope ratio (NIR; 15N/14N) was used as a validated measure of n-3 PUFA intake to select 165 participant samples from the first and fourth quartiles of n-3 PUFA intakes. Outcomes included 38 pro- and anti-inflammatory cytokines and 8 measures of glucose homeostasis associated with type 2 diabetes risks. These outcomes were evaluated for their associations with direct measurements of EPA, DHA, and arachidonic acid in RBCs. ANALYSIS: Linear regression was used to detect significant relationships with cytokines and n-3 PUFAs, adiposity, and glucose-related variables.

resultsThe DHA concentration in RBC membranes was inversely associated with IL-6 (β = -0.0066; P < 0.001); EPA was inversely associated with TNFα (β = -0.4925; P < 0.001); and the NIR was inversely associated with Monocyte chemoattractant protein-1 (MCP-1) (β = -0.8345; P < 0.001) and IL-10 (β = -1.2868; P < 0.001).

conclusionsHabitual intake of marine mammals and fish rich in n-3 PUFAs in this study population of Yup'ik Alaska Native adults is associated with reduced systemic inflammation, which may contribute to the low prevalence of diseases in which inflammation plays an important role.

Indexed as

Alaska NativesCardiovascular DiseasesDiabetes Mellitus, Type 2Fatty Acids, Omega-3AnimalsCross-Sectional StudiesCytokinesFishesGlucoseHumansInflammationMammalsCytokinesFatty Acids, Omega-3Glucosechemokinescytokinesfish oilimmune biomarkersomega fatty acids

Identifiers

PMID34871429
PMCPMC8891177
OpenAlexW4200273836

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.