ArticlePsychiatry research. Neuroimaging2022
Does obesity-associated insulin resistance affect brain structure and function of adolescents differentially by sex?
Article in Psychiatry research. Neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Evaluating bidirectional, longitudinal associations between adolescent executive control and eating behaviors.Appetite · 2026Article
- Sex Differences in the Association Between Body Composition and Cognitive Performance in Adolescents With Type 1 Diabetes.Diabetes/metabolism research and reviews · 2026Observational
- Review
- Fetal cortical development and neurosonographic findings in obese pregnant women: a case control study from a tertiary hospital.Archives of gynecology and obstetrics · 2024Article
- Pre-diabetes is associated with altered functional connectivity density in cortical regions of the default-mode network.Frontiers in aging neuroscience · 2022Article
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4 authors.
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Abstract
Metabolic abnormalities affect the adolescent brain. For equivalent abnormalities in metabolism young people exhibit deficits in more cognitive domains than adults. We examine sex differences performance for adolescents with obesity/insulin resistance (IR) and evaluated how sex and IR effected frontal lobe structures and executive functioning. 125 adolescents underwent medical, cognitive, and brain-imaging assessments. Participants were categorized as insulin sensitive (IS) (QUICKI ≥ 0.350) or IR (QUICKI < 0.350). Degree of IR may affect brain and cognition differentially by sex. Females had positive associations between QUICKI and anterior cingulate cortex (ACC) volume, medial orbito-frontal cortex (OFC) thickness, and scores on the Stroop and Digit Symbol Substitution (DSST) tests. Females with IR tended to have thinner insular cortices. No such associations were found in males. In female adolescents, IR may negatively affect brain structure and function. No such effects were found for males. Although needing more development, hormonal effects and inflammation are potential contributors.
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